I was just looking at my mdapps and realized that I will interview at at least 8 of the 11 schools I applied to this year. This is a drastic change from the 1/12 the first year and 4/12+ the second year.
The best piece of advice that I got was to be confident and sell yourself in your essays, description of activities, and in interviews. I don't think that my GPA or MCAT score improvement is what did it for me, I think that the way I changed the wording of my own activities portrayed them as more important and meaningful.
Instead of just saying "I worked in an SICU for 12 months," I would say things like "Was responsible for monitoring patient glucose, input/output volumes, assisting nurses with basic patient care duties, and being prepared for emergency life saving actions (CPR) in a surgical/trauma intensive care unit."
I also rewrote my PS to remove almost all "negative" comments about anything, except when I very briefly addressed the weaknesses of my application (my grades).
So if you are in the position where you have to reapply again, make sure you're putting your best foot forward. Let them think that you've got all of the experience, confidence, and maturity not only to be successful, but to be a highly desirable applicant.
oh yeah, and make sure your LORs are strong. I used a LOR I knew was weak and shot myself in the foot.