Have you ever taken psychiatric medicines to know what they feel like?

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birchswing

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I understand that you can read studies on the effects of medicines, try to figure out how they work, and you can follow patients and see how they improve or get worse on a medicine, but I'm wondering if you've ever taken the medicines so could more intimately know what the experience is like? And if you've not done so because it would be legally or ethically difficult, is it something you would want to do? If you have tried any of them, have you seen a benefit to doing so in communicating with patients about medicines or deciding on treatment options?

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That makes sense. I suppose the effects aren't terribly exotic.

When I think of the subject, researchers like Timothy Leary come to mind (he advocated and personally used LSD and psilocybin).

I also think of how psychologists and psychiatrists normally participate in therapy in their training.

I can understand how the psychiatric drugs of today are considered run-of-the-mill, so why would you take one anymore than you would take a hypertension drug if you didn't have hypertension? But I would argue the nature of altering the psyche is very different and much more personal, like therapy. You can measure reductions in hearing voices or anxiety, etc., but the medications create broader experiential changes.
 
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In the early days of psychopharmacology, psychiatrists used to try the different psychopharmaceuticals. Some of these older psychiatrists who are still alive today suggest that one of the problems with psychiatry today is that psychiatrists don't try these drugs to know what they feel like. The older neuroleptics like thorazine for example are absolutely soul crushing for non-psychotics to take, they render you apathetic to the environment around you. This was important to know in order to understand how the drugs work, and the role of dopamine in motivational salience. The argument from a research perspective is more persuasive than for clinical psychiatrists to all be taking these drugs, but we really have neglect the "psycho" part of psychopharmacology in recent years. Very little research has looked at the actual psychological effects of these drugs. There have been some studies for example looking at how antidepressants dull emotions and the phenomenology of that, but for the most part we have spent too much time on brain imaging, genetics, and molecular studies, and thus a really important strand of research has been neglected. Sitting on a shelf somewhere could be the latest psychopharmacological breakthrough (unlikely, but possible) and researchers would do well to try these out for themselves.

Timothy Leary is IMHO not a good example. As a psychologist he would not ordinarily have been given LSD. He got pharmaceutical grade LSD from Sandoz (who also marketed Clozaril incidentally) and the only reason they gave it to him was because he was on the faculty at Harvard. The whole incident really traumatized the Harvard psychology department and they were very wary about being too experimental or controversial (for example they opted not to give Stanley Milgram a faculty position and he served out the remainder of his years at CUNY), and set back psychedelic research back many years. It's only now that we are again seeing a slight resurgence in psychedelic research.

Edit: also while shrinks dont go trying out samples of things for themselves many psychiatrists have taken some kind of psychotropic drug. I would say >50% of my residency class was taking one or more agent, including benzos, lithium, antipsychotics etc. I read a study some years back that found unsurprisingly psychiatry residents all happily disclosed having their own therapy (which often encouraged and perhaps there is a parallel here), but more reluctant to diclose taking psychotropics.
 
Not me. I used to work with a few older psych nurses who would tell stories about how when they trained it was acceptable and encouraged "back in the day" to test out PRN meds that they were administering to patients. I remember one had slept through a weekend after taking 25mg of CPZ, so you sort of knew that whenever they asked for a phone order for a patient they weren't mucking around.
 
The closest I've gotten to taking any sort of psychiatric medication was a little bit of Compazine...for nausea. It was ok. Definitely helped me sleep, which was a good thing.

You know, I have thought about the fact that I can never completely understand how it really feels to have a psychotic episode or to be extremely depressed (which I am thankful for since I understand enough to realize that it would be a terrible experience to go through). I'm not sure that being able to empathize with the patient experience would actually change how I treat it, though - and there is the chance that overly identifying with the patient could lead to problems.
As it is, when patients tell me that a medication makes them feel bad, I believe them and try to find something they do find acceptable, even though I can't totally understand how it feels to them.
 
I understand that you can read studies on the effects of medicines, try to figure out how they work, and you can follow patients and see how they improve or get worse on a medicine, but I'm wondering if you've ever taken the medicines so could more intimately know what the experience is like? And if you've not done so because it would be legally or ethically difficult, is it something you would want to do? If you have tried any of them, have you seen a benefit to doing so in communicating with patients about medicines or deciding on treatment options?

This also strikes me unnecessary, and frankly just bizarre.

The effect of the drugs on me would likely be different...because I do NOT have the psychiatric disorder for which they are indicated. Oncologist dont give themselves chemo drugs either...because its dangerous, a waste of resources, and has no evidence that it would improve outcomes.
 
This also strikes me unnecessary, and frankly just bizarre.

The effect of the drugs on me would likely be different...because I do NOT have the psychiatric disorder for which they are indicated. Oncologist dont give themselves chemo drugs either...because its dangerous, a waste of resources, and has no evidence that it would improve outcomes.

The difference is that we actually give medications to people who may or may not have the disorder that we think we're treating. We also force/coerce medications into people much more frequently than oncologists. I think this concept is more equivalent to a law enforcement officer being tazered to appreciate the effects of the weapon.
 
The difference is that we actually give medications to people who may or may not have the disorder that we think we're treating. We also force/coerce medications into people much more frequently than oncologists. I think this concept is more equivalent to a law enforcement officer being tazered to appreciate the effects of the weapon.

Ok. Does/would this practice improve health outcomes? If not, then I have would zero inclination to expose myself to drugs that **** with my, largely normal, emotional/neuro functioning.
 
Cannot compare normal brains to abby normal ones.
You really don't need to see how different sedative/hypnotics work as your brain chemistry is different than others.
 
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I heard that where I trained they gave a dose of Mellaril to the residents in the 70s. It is true that people with schizophrenia experience some side effects at a lower rate with antipsychotics.
 
Never have taken any psych meds, but do wonder what it feels like. If there were some hypothetical setting where it was considered professional and ethical to do so, I would definitely be curious to see what 5mg of haldol feels like.
 
The difference is that we actually give medications to people who may or may not have the disorder that we think we're treating. We also force/coerce medications into people much more frequently than oncologists. I think this concept is more equivalent to a law enforcement officer being tazered to appreciate the effects of the weapon.

Yeah, I feel like maybe we ought to get a B52 at some point during orientation to learn appropriate respect.

Many police also get sprayed in the face with ORC (pepper spray) during training as well.
 
Thanks for the link to the summary. When I was a student, I would literally read scientific journals out of pure interest and curiosity. Now that I work for a living, I avoid reading scientific articles like the plague unless it directly applies to patient care. Since none of my current patient load are psychiatrists and I don't plan on taking psychotropics myself, definitely appreciate the cliff notes. 🙂
 
Indeed I have
https://forums.studentdoctor.net/threads/sampling-antipsychotics.498756/

birchswing said:
If you have tried any of them, have you seen a benefit to doing so in communicating with patients about medicines or deciding on treatment options?

I think the experience gave me a healthy respect for the potential that even very low doses of medication can have quite intolerable side effects. I try to do a good job listening to people generally but I think that due in part to this experience above, I'm perhaps less likely than others I know to dismiss complaints of side effects just because the dose is low.
 
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Indeed I have
https://forums.studentdoctor.net/threads/sampling-antipsychotics.498756/



I think the experience gave me a healthy respect for the potential that even very low doses of medication can have quite intolerable side effects. I try to do a good job listening to people generally but I think that due in part to this experience above, I'm perhaps less likely than others I know to dismiss complaints of side effects just because the dose is low.
Very interesting. I was on low dose Zyprexa for a very short time and didn't mind it but was switched to low dose Seroquel (the indication for both was tics). The first time I took low dose Seroquel (50 mg) before bed was one of the most terrifying experiences I've had. I hate losing control. It wasn't like a sleepy, sedated, "Oh it would be nice to sleep now" type feeling. It felt like I had no control over whether I could stay awake or not (more like a "turn off" than go to sleep feeling), and my instinct was to fight it tooth and nail, which I did. So I started taking it at the point when I was almost about to fall asleep anyway. From what I've read of Seroquel, higher doses wouldn't necessarily be more sedating, so you may have gotten some of the scarier effects even at the lower doses.
 
Very interesting. I was on low dose Zyprexa for a very short time and didn't mind it but was switched to low dose Seroquel (the indication for both was tics). The first time I took low dose Seroquel (50 mg) before bed was one of the most terrifying experiences I've had. I hate losing control. It wasn't like a sleepy, sedated, "Oh it would be nice to sleep now" type feeling. It felt like I had no control over whether I could stay awake or not (more like a "turn off" than go to sleep feeling), and my instinct was to fight it tooth and nail, which I did. So I started taking it at the point when I was almost about to fall asleep anyway. From what I've read of Seroquel, higher doses wouldn't necessarily be more sedating, so you may have gotten some of the scarier effects even at the lower doses.

interesting, some people LOVE that aspect of Seroquel.
a lot of patients are looking for the "off" switch - I think opiates, alcohol, ambien, benzos, even Benadryl pose serious dangers for this reason

everyone is different, so I'm not sure how instructive it is to have psychiatrists take the same meds as patients

the way I thought of my script writing, was that EVERY SINGLE ONE was essentially an "individual human experiment"

we do studies to get the general trend/idea what a drug will do in specific populations, while recognizing the following:
1) the results are only "generalizable" to a limited degree in a population that resembles the small population of patients studied
2) even in the case of 1), what I said about individual response, is true

so I second what has been said that whatever "knowledge" is gained by the psychiatrist taking the same med as a patient, is likely to be of limited value

lastly, one of my favorite lessons about treatments:
every treatment has chance of benefit, and risk of harm
how much of either is possible depends on a lot of factors
I won't go into how to actually appraise the two to come to a treatment decision,
but it's clear (here's the pearl!)
that an intervention that you believe has no chance of benefit, therefore only exposes a patient to risk of harm
the principle of "first do no harm" would then apply

say you are bleeding out in the ED
we are going to give you an IV bag of fluids
chance of benefit >>>>>> risk of harm

risk of harm from IVs is very low. however, I'm not coming over to your house to give you one tonight. Because you can drink by mouth and your volume status is fine. No expected benefit. It's easy to take this intervention for granted. However small the risk, there is a risk of anaphylaxis from the tubing (ANY time one is given, in fact, most PCPs won't do them outpt, they should never be done if there is not a crash cart available), risk of thrombophlebitis, infection, sepsis, endocarditis, even PE & death. These risks are actually pretty low, and you can imagine in 99% of hospital scenarios where you are given one, it makes total sense.

However, do you think I should just come over to your house and poke you for an IV just so you can see what it's like? Ethically I cannot as a physician because all I am doing is exposing you to risk of harm.

TLDR:
a treatment with no expected benefit therefore only exposes a patient to risk of harm
 
interesting, some people LOVE that aspect of Seroquel.
a lot of patients are looking for the "off" switch - I think opiates, alcohol, ambien, benzos, even Benadryl pose serious dangers for this reason

everyone is different, so I'm not sure how instructive it is to have psychiatrists take the same meds as patients

the way I thought of my script writing, was that EVERY SINGLE ONE was essentially an "individual human experiment"

we do studies to get the general trend/idea what a drug will do in specific populations, while recognizing the following:
1) the results are only "generalizable" to a limited degree in a population that resembles the small population of patients studied
2) even in the case of 1), what I said about individual response, is true

so I second what has been said that whatever "knowledge" is gained by the psychiatrist taking the same med as a patient, is likely to be of limited value

lastly, one of my favorite lessons about treatments:
every treatment has chance of benefit, and risk of harm
how much of either is possible depends on a lot of factors
I won't go into how to actually appraise the two to come to a treatment decision,
but it's clear (here's the pearl!)
that an intervention that you believe has no chance of benefit, therefore only exposes a patient to risk of harm
the principle of "first do no harm" would then apply

say you are bleeding out in the ED
we are going to give you an IV bag of fluids
chance of benefit >>>>>> risk of harm

risk of harm from IVs is very low. however, I'm not coming over to your house to give you one tonight. Because you can drink by mouth and your volume status is fine. No expected benefit. It's easy to take this intervention for granted. However small the risk, there is a risk of anaphylaxis from the tubing (ANY time one is given, in fact, most PCPs won't do them outpt, they should never be done if there is not a crash cart available), risk of thrombophlebitis, infection, sepsis, endocarditis, even PE & death. These risks are actually pretty low, and you can imagine in 99% of hospital scenarios where you are given one, it makes total sense.

However, do you think I should just come over to your house and poke you for an IV just so you can see what it's like? Ethically I cannot as a physician because all I am doing is exposing you to risk of harm.

TLDR:
a treatment with no expected benefit therefore only exposes a patient to risk of harm
Interesting. Totally off topic, but I know of people with dysautonomia (POTS specifically) who get home care saline infusions. I believe they already have a port. Not sure if it has the same risks or not as an IV with regard to anaphylaxis and other issues you mentioned.

Edit:
I don't need IV fluids personally, but I've seen this video pop up before in dysautonomia communities (at the end of it the "patient" says her husband is becoming trained to administer IV fluids at home):
 
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Interesting. Totally off topic, but I know of people with dysautonomia (POTS specifically) who get home care saline infusions. I believe they already have a port. Not sure if it has the same risks or not as an IV with regard to anaphylaxis and other issues you mentioned.

Edit:
I don't need IV fluids personally, but I've seen this video pop up before in dysautonomia communities (at the end of it the "patient" says her husband is becoming trained to administer IV fluids at home):


~~~~~OFF TOPIC SKIP IF YOU WANT~~~~~~

Ports are used specifically because they are different from PIVs (I didn't specify I meant peripheral IVs before) and the risks associated with them are different, but the decision to use a port over an IV is one of necessity since they pose greater risks longterm overall. The reality is that for repeated infusions and/or for certain medications, a little wimpy peripheral vein is not going to cut it and a port is more practical.

The material in an implanted port is more "sturdy", "hypoallergenic", and is specially coated to decrease the main risks of leaving a plastic tube in someone: clotting & bacterial growth, vs PIV tubing, which is cheaper & meant for much shorter term use (I believe most hospitals will change PIV tubing every 3 days, I could be wrong on the exact number. It's less than 10 days for sure.)

I don't know much about home care infusions in all honesty, except that I know they have special training to not only reduce infection risk in administration, but to recognize signs of complication from the port or the infusion. I wouldn't be surprised if they also carried an epi pen (I know the most common dangerous adverse infusion reaction overall is anaphylaxis, although the most common overall is allergic, not all allergic reactions are equally dangerous) but there I am only speculating.

Even the medical decision to use an epi pen for "rescue" has a whole host of factors to consider.

Look at IVDU if you want to see the harm that "simple" stabbing yourself with a needle, into or not into a vein, can do. And that's not just cuz they're using dirty needles, injecting dirty stuff, or not using sterile technique. Risk still isn't zero even when it's done in the hospital.

I don't know much about standard of care regarding patients doing self administered PIVs.

I don't think they're a good idea, even in health care professionals that know how to do them "properly."

~~~~BACK ON TOPIC~~~~

I know this was off topic, I just wanted to address some reasons I can think of for why certain home interventions that are seemingly "harmless" that patients with a surface understanding may think "why can't I MacGuyver this at home, I watch them do it in the ED 1000x it hardly looks like rocket science," actually require a deeper understanding of how things work, risk vs benefit, possible negative outcomes (even if rare), and how to respond in those scenarios.

In our training, and related a little to what I said above about people seeing medical stuff happen and then getting the sense they could do it themselves, we are all told the stories of scientists that did some of their own science on themselves to advance the field.

Ethically, besides the issue of possible self-harm, is the question of a loss of objectivity.

As we discussed, yes, psychiatry is a field where, more than a lot of fields of medicine, the outcomes we are trying to effect, are for the most part, subjective. You need some subjectivity in your psychiatrist. You also need some objectivity.

If you have a suicidal, homicidal, psychotic patient, the "fear of the off switch" from a personal experience with Seroquel swaying your prescribing hand could be a total disservice depending on the whole picture. In a perfect world you would not factor that into your prescription, but cognitive biases are sure to remain.

All doctors are expected to appreciate side effects and the patient's subjective report, however, that doesn't mean we must *experience* the same. Experience clouds all our judgment to some extent.

Getting into projection and transference/countertransference, I would argue that while there is GREAT value in using the ways your experience overlaps with a patient's in order to help them (my example is my prior personal experience with cigarette smoking cessation), that is also when as a physician you need to be the most CAUTIOUS in maintaining objectivity. It can harm as much as it helps.

I would rather psychiatrists did not take the medications they prescribed, so that they would be more guided by objective studies, and clinical experience in observing harm/benefit in patients with specific conditions. Those I believe will act as more unbiased and appropriate guides. (exception being when a psychiatrist has to take a psych med as Rx'd by their tx'ing provider)

I could paint you a picture for how this could happen with, say, anxiety and benzos. Or Adderall and ADHD.
I won't say that I have taken psych meds for/not for psych conditions, except to say that I really believe the experience of the sufferer vs not sufferer for so many of these drugs is distinct enough that truly, no reason to bother. I see greater risk of the development of negative biases in prescribing needed meds than an increase in sympathy for side effects, etc etc
 
If you have a suicidal, homicidal, psychotic patient, the "fear of the off switch" from a personal experience with Seroquel swaying your prescribing hand could be a total disservice depending on the whole picture. In a perfect world you would not factor that into your prescription, but cognitive biases are sure to remain.
How would this be different than a hesitation about using Seroquel that arose from, for example, having had a patient who completed suicide after taking it?

All doctors are expected to appreciate side effects and the patient's subjective report, however, that doesn't mean we must *experience* the same. Experience clouds all our judgment to some extent.
Au contraire, every single thing we know is the result of some type of experience.
I'm having trouble seeing how additional channels of information constitute a negative. Published research is one channel of information, clinical experience is another channel of information, written or spoken testimonials from patients could be another channel, and personal experience can be yet another channel, although obviously the amount and relevance of the information coming through that channel is limited in its application to clinical situations. That's quite different from saying it would be actively harmful.

I would rather psychiatrists did not take the medications they prescribed, so that they would be more guided by objective studies, and clinical experience in observing harm/benefit in patients with specific conditions. Those I believe will act as more unbiased and appropriate guides.
I don't believe a single dose of Zyprexa nine years ago has so addled my thinking that I'm unable to use published research and clinical observation to guide my treatment. That seems... silly.

I really believe the experience of the sufferer vs not sufferer for so many of these drugs is distinct enough that truly, no reason to bother.
I'm very curious about the basis for this statement. In my experience, the range of responses to the very same medication among psych patients can be enormous, ranging from 'I couldn't tell I was on it' to 'horrible' to 'incredibly helpful.'

I also think the idea of a bright line between the experience of a 'psychiatric patient' and a 'neurotypical' is hogwash. Psychiatric disorders mostly seem to represent the extreme ends of spectra on which we all fall. We pretty much all have the potential to be manic/psychotic, it's just a matter of the threshold required to elicit that (as little as a shortened night of sleep in a serious bipolar I, ranging all the way to massive doses of methylprednisolone or amphetamine in those who are most psychiatrically stable/resistant).
 
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Not in residency yet but taking Xanax and various amphetamines helped give me some perspective. The speedy effects of amphetamines can be quite overwhelming.

I see there is some LSD discussion earlier in this thread and personally I think this has real potential to be therapeutic. LSD is an incredibly introspective and beautiful experience.
 
I don't believe a single dose of Zyprexa nine years ago has so addled my thinking that I'm unable to use published research and clinical observation to guide my treatment. That seems... silly.

I don't think that the original quote was implying that medication altered your cognition so that you were incapable of objective thought. Rather, the argument is that you are now biased against prescribing olanzapine because of your negative experience, even if clinically indicated.

I would argue that objectivity is overrated in medicine. Look at any essay or book in which a doctor becomes a patient (the best written and most accessible being When Breath Becomes Air). None of them talk about how appreciative they were for evidence based medicine or having an objective provider. They pretty much all talk about how much they assumed or didn't appreciate when they were in the position of clinician (for example, Paul Kalanathi talks about the salty taste he experienced with IVF, something he ordered without thought thousands of time).

It's easy to put an order in or send in a prescription. It gets harder when you realize there's a human on the receiving end of that order, or putting that medication into their body. Maybe we would order less tests or overtreat patients if we understood that better.
 
Oh you crunchy crumpet, the humor of mel brooks passes you up.
tumblr_lz7ed1ciW71r5uuddo5_500.png
 
Have I taken these drugs? No friggin' way. To be quite honest, they scare me. We just don't have enough information on the effects of these medications to where I would feel comfortable taking them. The only psychotropic drug I currently take is caffeine and if I wasn't addicted to it, I would probably not be able to rationalize that risk/benefit ratio either. Many of my patients take various medications and for some they are essential. If I had psychosis or mania or severe depression, then that would change the cost benefit analysis, obviously. I don't so am not messing with my brain chemistry except through non-chemical means. Group therapy, skiing, basketball, sex, cooking and eating healthy foods, gardening, music, art, socializing with family and/or friends, crying, laughing, yelling, praying, reading journal articles, working, meditation, and even a little SDN activity. There are a lot of ways to accomplish this and when my patients figure some of this out they have much better outcomes than they do when they think a medication will improve their life.
 
Given the side effects, especially risk for qt prolongation with some, I am surprised to hear so many physicians think its advisable to take a medication when one lacks the debilitating conditions/symptoms that its designed to be indicated for.
 
Given the side effects, especially risk for qt prolongation with some, I am surprised to hear so many physicians think its advisable to take a medication when one lacks the debilitating conditions/symptoms that its designed to be indicated for.

It's not, like, medically advisable since there's no medical benefit. But I wouldn't say it's dangerous. You're not going to get torsades from one dose of an antipsychotic. Neither are you going to do permanent damage to your 'brain chemistry.' There are very few drugs where you can do permanent damage to yourself with a single dose that is within the recommended dosage range. LSD for sure, if you happen to have a bad trip. Cocaine if you happen to get an MI or brain hemorrhage from it.

Chronic administration and overdoses are a whole other story.
 
I've been on three in my life and they all made me feel so terrible I stopped taking them. My depression and ADHD faded over the years, and I'm totally fine now, but I'll always remember how prozac, bupropion, and adderall felt. That being said, patient experiences vary widely with medications, so what was awful for me might be fine for another person, just as alcohol or recreational drugs seem to affect people differently from one another (the angry drunk, the fun drunk, the guy you knew in high school that would get paranoid when smoking pot versus the bone that would become a mini Carl Sagan, etc). It would be foolish to assume what I feel is what everyone else feels on a med.
 
I was prescribed venlafaxine er at one point many years ago.

Brain zaps. Night sweats. Immediate discontinuation syndrome if I missed a dose by as little as an hour. A nightmare to get off of.

I don't prescribe it unless asked. And if someone comes to me on it and complains of these things, I've worked out this whole thing with fluoxetine to make getting off of it as painless as possible.

Having said that, when people tell me they're doing great on Effexor (and some are), I don't argue with them.


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I was prescribed venlafaxine er at one point many years ago.

Brain zaps. Night sweats. Immediate discontinuation syndrome if I missed a dose by as little as an hour. A nightmare to get off of.

I don't prescribe it unless asked. And if someone comes to me on it and complains of these things, I've worked out this whole thing with fluoxetine to make getting off of it as painless as possible.

Having said that, when people tell me they're doing great on Effexor (and some are), I don't argue with them.


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Dont worry! We now have DESvenlafaxine, for a few thousand dollars a month we made some of those things somewhat better!

(For the record I understand Pristiq is actually a bit functionally different as a drug)
 
I was prescribed venlafaxine er at one point many years ago.

Brain zaps. Night sweats. Immediate discontinuation syndrome if I missed a dose by as little as an hour. A nightmare to get off of.

I don't prescribe it unless asked. And if someone comes to me on it and complains of these things, I've worked out this whole thing with fluoxetine to make getting off of it as painless as possible.

Having said that, when people tell me they're doing great on Effexor (and some are), I don't argue with them.


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Prozac.
 
Dont worry! We now have DESvenlafaxine, for a few thousand dollars a month we made some of those things somewhat better!

(For the record I understand Pristiq is actually a bit functionally different as a drug)

Heh. I've also taken both celexa and lexapro and I swear lexapro is better. I mean, I know they're the same thing. But lexapro is better.

I do preferentially prescribe celexa though because it's less expensive.
 
Heh. I've also taken both celexa and lexapro and I swear lexapro is better. I mean, I know they're the same thing. But lexapro is better.

I do preferentially prescribe celexa though because it's less expensive.

Lexapro is basically the same price as Celexa where I am actually. And I do actually prefer it, it weird's me out to see people prescribe Celexa. Im not sure it has less QTc prolongation, but it sure makes me feel better.
 
Mirtazapine did in fact make me gain weight :/

Maybe not a bad thing, it's basically the main reason to use the drug at this point. Being on CL through an onc ward I just want a bag of Remeron and one of those tee shirt guns to blast it into each room.
 
One time I took a handful of Xanax and Klonopin and woke up with my pants off in my cousin's bed. I never did that again....
 
Heh. I've also taken both celexa and lexapro and I swear lexapro is better. I mean, I know they're the same thing. But lexapro is better.

I haven't tried either of those myself but have also reached this conclusion based on patient reports.
I also stay away from Celexa because of the 40mg dose ceiling and the QT interactions with other frequently used meds. Lexapro also seems to cause less sexual dysfunction than Celexa.
I don't switch people off if they come to me on Celexa but it's not my first choice if trying something new.

By the way they aren't the same thing. The two enantiomers of Celexa appear to bind the serotonin receptor in different orientations and at a secondary site, and binding of the R isomer can kick out the S isomer.
https://www.ncbi.nlm.nih.gov/pubmed/20055463
https://www.ncbi.nlm.nih.gov/pubmed/19616061
https://www.ncbi.nlm.nih.gov/pubmed/16918708
 
In college I had terrible insomnia isolated only to night before exams, got my pcp to Rx a couple zaleplon and it was pretty incredible, take one, within 30 minutes felt like I couldn't feel stress anymore and within 45 minutes asleep. Would wake up after about 7 hours with feeling it wore off then sleep a little more more before getting up for the test and no hang over.

Probably gives me some perspective on understanding why everyone wants benzos so badly, but doesnt make me any more likely to Rx them.
 
Yep, quite a few, all prescribed for actual diagnosed conditions.

Sinequan - Hello land of the walking zombies.
Amitriptyline - Hello paradoxical suicidal reaction.
Zoloft - Hello instant manic freak out.
Xanax - Hello spawn of satan
Dextroamphetamine - Hello kinda awesome medication that worked for two weeks before the side effects began to outweight the benefits.
Effexor (on top of a high dose of Tramadol) - Hello trip to emergency with serotonin syndrome.
Topirimate - Hello one sided partial paralysis with loss of sensation, slurred speech and sudden onset of fever.
Deptran - Hello weight gain and bloating, but I forgive you because you did at least work.
Seroquel (round 1, titrated up to a maximum dosage of 1000-1200 mgs) - Hello rapid 40 pound weight gain from non stop binging and eventual onset of EPS.
Seroquel (round 2, titrated up to a maximum dosage of 300 mgs) - Hello wonderful medication that I had to stop due to onset of weird heart stuff happening.
Valium - Hello helpful medication, sorry we'll be breaking up soon because I've found a better alternative (not actually for psychiatric use).
Olanzapine - Okay you made me gain a few kilos, but Hello, I love you, can I take you again.
Mirtazapine - Hello best antidepressant I've ever tried, I don't even care that you made me gain 4-6 kilos.
 
OP trying some psych meds be like

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I took a dose of Modecate back in my younger days, because someone told me it was a major tranquiliers and stupid me went 'Cool, so it's like a benzo only way better'. Didn't have quite the effect I was looking for, unless of course I was looking to be nailed to my lounge room floor whilst drooling and mumbling incoherently for several hours, which I wasn't.
 
Yea, the side effects can be pretty bad in SSRIs (prozac in this case). Dizziness and nausea is what I felt for the first 2 days, then it gradually got better. Had some experience with benzos as well. They make me feel more sleepy than calm.
 
I know an attending who likes to tell the story of the time he tried Haldol as a resident. It made him feel "so slow and stupid" that he had to use a sick day to recover.
 
Yea, the side effects can be pretty bad in SSRIs (prozac in this case). Dizziness and nausea is what I felt for the first 2 days, then it gradually got better. Had some experience with benzos as well. They make me feel more sleepy than calm.
Benzos vary a good deal. Valium is quite soporific (which is one reason some doctors are reluctant to do an entire crossover from a short-acting benzo to Valium at once). Ativan, in my experience, is not soporific at all, just relaxing. I could see how Valium would make someone sleepy and not calm, as I personally hate to lose control. The first time I took Valium it also made my pulse drop significantly, which worried me and I actually had a panic attack from taking Valium due to the fear over bradycardia (and the panic didn't even raise me out of bradycardia). No literature I can find says that should be an expected effect or side effect, but Ativan never had that effect on me.
 
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