Hemolytic disease of the newborn

[ctizzle13498]

Why does first aid say "Rh antigent immunoglobulin is given to mother after deleivery to prevent future erthroblastosis"

What does this mean?

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[notarealname]

Why does first aid say "Rh antigent immunoglobulin is given to mother after deleivery to prevent future erthroblastosis"

What does this mean?

If the mother is Rh- and the baby is Rh+, the Rh antigen immunoglobulin bind to the Rh+ antigen on RBC from baby (during/) after delivery and remove them from getting an immune response from the mother. Note that because of the placental barrier, the Rh- mother immune system don't usually see the Rh+ fetus RBC. So that when next time the Rh- mother has a Rh+ fetus, the mother won't produce antibody against the fetus RBC.

I probably need to review this subject too, can someone else help?

 

[CatFactorial]

Basically that. If the mom is Rh-, Rh+ will be considered foreign. Providing mom with antibodies to baby's Rh+ will clear her system of Rh+ antigen so that she doesn't develop immunity to Rh+. Otherwise, she will build up immunity and future Rh+ fetuses will be subject to hemolysis because her anti-Rh+ IgG can cross the placenta.

 

[pbnj003]

would this be considered active or passive immunization?

there was a question on NBME 6 that I kinda got confused about.
there were options for Active immunization to IgM or IgG etc.
and passive immunization.

 

[turkeyjerky]

would this be considered active or passive immunization?

there was a question on NBME 6 that I kinda got confused about.
there were options for Active immunization to IgM or IgG etc.
and passive immunization.

This is Passive immunization--you're giving immunoglobulin to the mom. The baby's rbcs activel immunized the mom against Rh antigen, which is what you are preventing.