Hemostasis question

[MudPhud20XX]

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Here is one of the Kaplan questions:

An experimental model is designed to investigate new therapeutic modalities for the treatment of myocardial infarction. The approach is to stimulate the production of endogenous antithrombogenic material rather than to inhibit the thrombogenic process. Which of the following would be a possible target for this intervention?

A. Kallikrein
B. Tissue factor
C. Thrombomodulin
D. Subendothelial collagen
E. von Willebrand factor

I chose D, but the answer is C. My reasoning for D was b/c the exposed subendothelial collagen is really the first trigger for the intrinsic coagulation cascade. Can anyone provide any explanation why C is the answer?
Many thanks in advance.

 

[Fatalis]

Your reasoning would be correct if the question asked what initiates coagulation but in this case the question asks what stops coagulation from happening. So thrombomodulin is the one that acts on thrombin and activates anti-coag. enzymes. Hope this helps.
Ps. I do miss answering your questions !

 

[J ROD]

Here is one of the Kaplan questions:

An experimental model is designed to investigate new therapeutic modalities for the treatment of myocardial infarction. The approach is to stimulate the production of endogenous antithrombogenic material rather than to inhibit the thrombogenic process. Which of the following would be a possible target for this intervention?

A. Kallikrein
B. Tissue factor
C. Thrombomodulin
D. Subendothelial collagen
E. von Willebrand factor

I chose D, but the answer is C. My reasoning for D was b/c the exposed subendothelial collagen is really the first trigger for the intrinsic coagulation cascade. Can anyone provide any explanation why C is the answer?
Many thanks in advance.

Thrombomod is a cofactor that coverts thrombin into activating protein C

 

[MudPhud20XX]

Your reasoning would be correct if the question asked what initiates coagulation but in this case the question asks what stops coagulation from happening. So thrombomodulin is the one that acts on thrombin and activates anti-coag. enzymes. Hope this helps.
Ps. I do miss answering your questions !

Yo Fatalis, how have you been man? Hope you aced the board exam. I am sure you did well. I am starting my MS2 this month, so I am less than 10 months away from taking step 1 next year. Thanks for your help and everyone's help on SDN!

 

[dyspareunia]

Yo Fatalis, how have you been man? Hope you aced the board exam. I am sure you did well. I am starting my MS2 this month, so I am less than 10 months away from taking step 1 next year. Thanks for your help and everyone's help on SDN!

Just starting MS2 as well. You'll be my SDN study buddy 😉

 

[MudPhud20XX]

Just starting MS2 as well. You'll be my SDN study buddy 😉

Dyspareunia, thanks! Let's nail it.

 

[Fatalis]

Yo Fatalis, how have you been man? Hope you aced the board exam. I am sure you did well. I am starting my MS2 this month, so I am less than 10 months away from taking step 1 next year. Thanks for your help and everyone's help on SDN!

Clinicals have been treating me well. Step 1 went really well and I am happy with my score. I lurk on this step 1 thread from time to time. It is great to see how hard you are reviewing for step 1. Keep at it 😀