1nycdoc8

10+ Year Member
5+ Year Member
Jan 3, 2008
166
0
91
Status
Medical Student
Hello everyone, I was wondering if you guys could tell me why there is no Hep b surface antibody found in chronic carriers. I find that there's a lapse in my immunology and I can't explain this blood finding. Thanks for all the help!
 

vicinihil

Member
Moderator Emeritus
10+ Year Member
Aug 12, 2004
1,583
4
241
Status
Resident [Any Field]
I think it's probably from the Anti-HbSAg binding to the HbSAg forming immune complexes that are getting cleared by macrophages so that's why you don't see them there.

You're probably not making more because your memory B cells have become anergic? Just a guess.
 

tncekm

MS-1
10+ Year Member
Jul 18, 2006
3,616
4
0
Status
Medical Student
Hello everyone, I was wondering if you guys could tell me why there is no Hep b surface antibody found in chronic carriers. I find that there's a lapse in my immunology and I can't explain this blood finding. Thanks for all the help!
Just a guess, because I don't know, but I'd wonder if it has anything to do with tolerance development.
 

username456789

7+ Year Member
May 24, 2009
4,617
7,153
181
Status
Attending Physician
vicinihil gets partial credit.

Straight from page 297 of Lange Immuno:

"Chronic carriers have negative antibody tests [HBsAb], but HBsAb is being made by these individuals. It is undetected in the tests because it is bound to the large amount of HBsAg present in the plasma. They are not tolerant to HBsAg."
 

1nycdoc8

10+ Year Member
5+ Year Member
Jan 3, 2008
166
0
91
Status
Medical Student
vicinihil gets partial credit.

Straight from page 297 of Lange Immuno:

"Chronic carriers have negative antibody tests [HBsAb], but HBsAb is being made by these individuals. It is undetected in the tests because it is bound to the large amount of HBsAg present in the plasma. They are not tolerant to HBsAg."
AHHHHHHHH YA. ya..... ya. ya.y ay.es. yes yessss thanks!!!!!!! I'll make sure to pick up a copy of that book for board studying