What kind of stuff are you interested in? If you want to do the tourist thing, I'm sure any google search will list the 10 or so landmarks you're "supposed" to go see.
There is plenty of good food here, ranging from high end to hole in the wall. Depends what you want, without knowing your preference, there's just too many to try an narrow down. Since you're from SoCal, I would say the stuff you can avoid here is Vietnamese, Japanese, and Korean. There are much better places to be found in LA/OC.
If this is your first time to SF, I would say to stay somewhere closer to Downtown/Union Square. It's more closely located to activities and sites. Will you have a car? I would advise not driving if you want to get more out of the city. SF is quite small area wise with a lot of different neighborhoods. Taking public transportation and doing a lot of walking will get you a better sense of the city. Besides, parking sucks here.
SF is pretty dense, bad neighborhoods border on good neighborhoods. The only area I would say to really avoid would be Bayview/Hunter's Point. There's nothing to really see there anyway.
PS. Are you going to change your screen name next year to Haisha Ni Natta?