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hi this is to help those who find biochem very difficult i would personally advise you to take kaplan classes short term 3 months which r nt that expensive if u really got to do nice in exam in ne consequence, ne ways just listen to biochem tapes of usmle part 1 and u will start loving biochemistry..........its so mind blowing explained in it...your all basics wil be cleared and u wont have to cram the subject ne more just for eg here is one topic from biochem: GLUCAGON activates protien kinase enzyme which is a phosphorylating enzyme and INSULIN activates protien phosphatase which is a dephosphorylating enzyme. Therefore in glycogenolysis which is stimulated pathway by glucagon and inhibited by insulin. Hence the rate limiting enzyme of it i.e. glcogen phosphorylase is activated i.e. glucagon phosphorlytates the enzyme because it stimulates protein kinase and if insulin dominates it activates protein phosphatase which will dephosphorylate the enzyme inactivating glycogen phosphorylase ..................Hence it answers our most imp quest of nbde that glycogen phosphorylase is activated when phosphorylated and inactivate when dephosphorylated i hope u guys understand it.........but may be my style is wrong that proffessor in biochem tapes is awesome i challenge u once u hear those tapes u will start loving the subject rest is upto u