HLA Class & Tissue Graft Rejection

[BUSM2008]

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BRS (2nd ed.) says HLA class I antigens are the principal Ags in tissue graft rejection

First Aid (2005) says HLA class II antigens are the principal Ags in tissue graft rejection

Which one is it?

 

[exmike]

Weird. Robbins says both (which makes sense). Levinson says MHC II

 

[raptor5]

Instead of thinking about which MHC Class Ag it is involved with, think about which immune cells are responsible for the damage. I agree with Robbins. Helper T's and Cytotoxic T's.

 

[felipe5]

yes, definitely helper T's and cytotoxic T's are important to remember for acute and chronic rejections, thus MHC II's are gonna play a definite role in those reactions (also, humoral immunity does its damage as well)...as for the MHC I role, keep in mind that hyperacute rejection takes place when preformed anti HLA antibodies bind to endothelial cell MHC I's and induce complement/neutrophil mediated damage