HOODIA
Also Known As:
Cactus, Hoodia Gordonii Cactus, Hoodia P57, Kalahari Cactus, Kalahari Diet, P57, Xhoba.
Scientific Name:
Hoodia gordonii.
Family: Apocynaceae.
People Use This For:
Orally, hoodia is used as an appetite suppressant for obesity and weight loss.
Safety:
There is insufficient reliable information available about the safety of hoodia.
Pregnancy and Lactation: Insufficient reliable information available; avoid using.
Effectiveness:
There is insufficient reliable information available about the effectiveness of hoodia.
Mechanism of Action:
The applicable parts of hoodia are the stems and roots. Hoodia is a succulent that grows in the Kalahari Desert. It is claimed that the San bushmen eat hoodia to stave off hunger during long hunts.
A specific component of hoodia extract is thought to be responsible for appetite suppressant properties. This constituent has been dubbed P57 (12002). This substance is thought to act centrally to stimulate sensations of satiety. The precise mechanism is not known.
Preliminary unpublished evidence suggests that overweight men who consume P57 have significantly lower calorie intake than those on placebo (12004). More evidence is needed to determine if hoodia is effective for any clinical condition.
Adverse Reactions:
None reported.
Interactions with Herbs & Supplements:
None known.
Interactions with Drugs:
None known.
Interactions with Foods:
None known.
Interactions with Lab Tests:
None known.
Interactions with Diseases or Conditions:
None known.
Dosage/Administration:
No typical dosage.
Comments:
The constituent of the hoodia extract called P57 is under development by Phytopharm. The company indicates that it has completed a positive study on the benefits of P57 for weight loss, but this study has not yet been published (12004). P57 was at one time licensed to Pfizer for development. Pfizer discontinued clinical development of P57 in 2003 (12003).
News reports suggest that some samples of hoodia products sold on the Internet show no evidence of containing actual hoodia (12002). Advise patients that they might not be getting what's listed on the label.
Source: Natural Medicins Comprehensive Database
Hoodia/Drug Interactions:
Insufficient available evidence.
Hoodia/Herb/Supplement Interactions:
Insufficient available evidence.
Hoodia/Food Interactions:
Insufficient available evidence.
Hoodia/Lab Interactions:
Insufficient available evidence
Source: Natural Standard