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If an applicant had a high overall GPA (over 3.8/3.9 lets say) and strong EC's/MCAT, would a single C on their transcript really do much damage? I mean to me, seeing a student with a C in something such as biochem or genetics could be a red flag showing they can't handle the med school curriculum. Probably a dumb question but some of my friends said their acceptance would be void if they got a single C (that was for PA school)