Sorry, I'm a little late to this thread, but I thought I'd add my two cents.
I applied to 29 schools this last cycle (28 of which were US MDs) under the guidance of my undergrad pre-med advisor. Out of those 28, I received zero interviews. Each rejection stung, but I always fell back onto the idea that I applied to so many that "I still had more to go". Once I got to the end of my long list full of rejections, I felt more of a numbness that entirety of the work I put into this last cycle didn't actually lead to anything.
This being said, I am extremely happy to be attending school outside of the US starting this summer. However, just knowing in *captain* hindsight that I could have skipped the AMCAS primary, secondaries (and saved soooooo much money), and still be in the same place I am now is pretty annoying to think about.
In the end, I assessed my first cycle, made of list of everything I could change to enhance my application, and if I was going to reapply, I'd be putting them into practice right now.