How do antbodies get into cells?

[chillaxbro]

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Ex: p-ANCA
Anti-mitochondrial
Anti-dsDNA
Anti-histone
Anti-scl70
Anti-U1

All are intracellular. How is it that antibodies can damage them?

 

[Dr.serotonin]

antibodies dont get inside the cells, its those antigens that are expressed when ever the cell is lysed as a normal wear and tear process.

 

[chillaxbro]

antibodies dont get inside the cells, its those antigens that are expressed when ever the cell is lysed as a normal wear and tear process.

Then how do u explain p-Anca vs c-anca patterns?

 

[chillaxbro]

Also dsDNA doesnt get presented on MHC because MHC is only presents protein

 

[Fission Chips]

I'm only matriculating this year, so take what I saw with a grain of salt. But I'm pretty sure Dr. Serotonin was talking about antigens (dsDNA) being loose in the ECM after lysis instead of the traditional MHC presentation.

As for the p-anca vs c-anca patterns, I don't really know enough about this yet but I thought the cells were fixated using EtOH, essentially insulting the membrane allowing antibodies in? Maybe somebody who is actually in medical school can comment on this train of thought?

 

[chillaxbro]

I'm only matriculating this year, so take what I saw with a grain of salt. But I'm pretty sure Dr. Serotonin was talking about antigens (dsDNA) being loose in the ECM after lysis instead of the traditional MHC presentation.

As for the p-anca vs c-anca patterns, I don't really know enough about this yet but I thought the cells were fixated using EtOH, essentially insulting the membrane allowing antibodies in? Maybe somebody who is actually in medical school can comment on this train of thought?

OIC i misread what he said. So they are antibodies that are formed after cells die and lyse and the contents spill into the blood. The autoantibodies we see in autoimmune diseases dont actually react to antigens of normal regular tissues. Makes sense since none of those are listed under Type II hypersensitivity reactions