How does Beta 2 agonist cause smooth muscle relaxation?

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

What the pho

Good to the last drop
7+ Year Member
15+ Year Member
Joined
Feb 25, 2003
Messages
179
Reaction score
2

Members don't see this ad.
I know in the heart beta 1 increases ca influx, increase ca atpase, and removes inhibition of phospholambam (spelling not sure). But how does beta 2 cause relaxation, esp beta 2 given to pregnant women to prevent uterine contractions? Thanks ahead of time.
 

Mossjoh

Mayo Clinic-PGY2
10+ Year Member
15+ Year Member
Joined
Jan 2, 2001
Messages
529
Reaction score
0
Its a G-protein mediated event through inhibition of myosin light chain kinase.
 

uclacrewdude

the uclacrewdude abides
7+ Year Member
15+ Year Member
Joined
Jul 28, 2003
Messages
9,796
Reaction score
7
kinda makes sense:
in cardiac myocytes ^ contractility & ^ hr = ^ CO
in smooth myocytes \/ contraction = \/ resistance = ^ flow
 
Top