how does digoxin increase automaticity of cardiac tissue?

[tarsuc]

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this topic has been dealt before but i dont think anyone has reached a consensus yet.

could someone simplify this for me?

http://forums.studentdoctor.net/showthread.php?t=724218

 

[tarsuc]

bump

 

[Wolverines83]

It doesn't

On top of increasing strength of contraction (na/k pump inhibition) digoxin:

1) slows conduction at the AV node
2) suppresses the SA node (inhibits sympathetic outflow to SA node)

These two things actually reduce transmission of afib to the ventricles.

So, it strengthens contractions (CHF) and reduces transmission of afib.

 

[OneMoreRound]

It doesn't

On top of increasing strength of contraction (na/k pump inhibition) digoxin:

1) slows conduction at the AV node
2) suppresses the SA node (inhibits sympathetic outflow to SA node)

These two things actually reduce transmission of afib to the ventricles.

So, it strengthens contractions (CHF) and reduces transmission of afib.

👍

 

[tarsuc]

thanks man!

 

[FIREitUP]

inhibition of Na/K ATPase causes the cells to be depolarized and more easily excited.