USMLE How is urobilinogen carried from gut to liver?

[Ludic_23]

Urobilinogen is formed by deconjugation of conjugated( water soluble) bilirubin by Large intestinal bacteria.

How then, does it circulate in blood back to the liver and get excreted in urine?

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[addidas]

5.30mins in

 

[aspiringmd1015]

only your bile salts go back to the liver, but your urobilinogen goes to your kidneys to get filtered and excreted as urobilin(yellow color to urine)

 

[Transposony]

Urobilinogen is colorless.
It has to go through Liver (Portal system) before reaching the systemic circulation in order for it to be excreted by the kidneys.
Urobilinogen is oxidized to urobilin which is responsible for the color of stool and urine.

 

[Ludic_23]

I get the pathway Bile salts and urobilinogen take. What perplexes me is how a deconjugated, non-water soluble compound travels in the circulation. Does it again bind to albumin for this, the way bilirubin did when it first came to the liver from the macrophages in spleen?

@aspiringMD: Somewhere around 10% urobilinogen goes back to the liver via enterohepatic circulation too. Subsequently a small fraction of it reaches the kidney, where it's oxidised form Urobilin gives the urine it's colour.

 

[Ludic_23]

watched addidas's video, and got the answer. Turns out it does bind to albumin for it's travel back to liver.

Thanks for your responses, everyone 🙂