Hyaline membrane in NRDS

[anbuitachi]

Why does neonatal respiratory distress syndrome cause hyaline membranes? Wiki says formation of hyaline membrane lining the collapsed alveoli. But if the alveoli is collapsed, shouldn't the vessels be constricted in that area... what is leading to the hyaline membrane formation ..? Thanks

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[TrueAntagonist]

Why does neonatal respiratory distress syndrome cause hyaline membranes? Wiki says formation of hyaline membrane lining the collapsed alveoli. But if the alveoli is collapsed, shouldn't the vessels be constricted in that area... what is leading to the hyaline membrane formation ..? Thanks

Hyaline membrane in NRDS occurs in phases.
1) transudate seeps into alveoli (due to pulmonary HTN as a result of acidosis-induced vasoconstriction + hypoxic vasoconstriction); point is, vasoconstriction --> transudate OR exudate if there's significant damage to surrounding tissue
2) alveolar (hyaline) membrane formation due to proteineceous material in alveoli and further worsening of hypoxemia.

Hypoxemia in NRDS is due to 1) collapsed alveoli due to insufficient surfactant and 2) alveolar hyaline membrane formation which decreases oxygen diffusion capacity.

Pretty sure I have that right but feel free to correct if I'm not.

 

[anbuitachi]

thanks!