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- Attending Physician
Hypericum has been shown in multiple trials, and in a large meta-analysis to be not inferior to some other SSRI's (direct comparisons vs. paroxetine and sertraline) and is about as effective vs. low-dose MAOIs. As we know, MAOIs and hypericum are not to be co-administered.
Some of these major randomized, double-blind, studies have come from Germany. Therefore, one could assert that the push for the use of hypericum in Germany isn't surprising.
I think it hasn't gained as widespread acceptance in the U.S. secondary to it's non-FDA approval for clinical depression, and multiple drug-drug interactions. Short-term studies have showed good tolerability, but of course, much larger, longer term studies should be carried out before it is deemed safe or acceptable.
Some of these major randomized, double-blind, studies have come from Germany. Therefore, one could assert that the push for the use of hypericum in Germany isn't surprising.
I think it hasn't gained as widespread acceptance in the U.S. secondary to it's non-FDA approval for clinical depression, and multiple drug-drug interactions. Short-term studies have showed good tolerability, but of course, much larger, longer term studies should be carried out before it is deemed safe or acceptable.
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My limited and anecdotal experience with St. John's Wort (n=2) have not impressed me with it's efficacy. However, both of these patient's presented to me because the herb was not working, which biases my limited data that much more. 😉
