HYPONATREMIA
Definition– Plasma sodium less than 135 mEq/L. Mild is 130-134, Moderate 125-129, Severe is <125 mEq/L
Incidence– 14% of hospitalized patients, up to 30% of ICU patients
Pathology– Relative excessive free water, depletion of plasma sodium, or both. CHF, cirrhosis, SIADH, and excessive water consumption leads to excessive free water. Diabetes mellitus may lead to hyponatremia with or without hyperglycemia. Severe hyperglycemia may result in osmotic shifts of fluids into the vascular space and dilutional hyponatremia in occasional patients with hyperglycemia at a rate of 2.4 mEq/l sodium reduction per every 100mg/dl blood sugar over 100. However, hyponatremia may also result from diabetic nephropathy without hyperglycemia and several other mechanisms.
Salt wasting (most common iatrogenic form of hyponatremia) may occur due to excessive diuretics, SSRIs, SNRIs, opioids, NSAIDs, PPI, ACE inhibitors, antiepileptic drugs including gabapentin, and amiodarone. The combination of thiazide diuretics plus SSRIs are especially prone to hyponatremia. Hyponatremia may be associated with an increase in ICP.
Symptoms (Severe)– confusion, ataxia, seizures, obtundation, coma, respiratory depression. Mild to moderate– lethargy, headache, dizziness.
Effects of Hyponatremia on Anesthesia– None intraop, but can cause excessive sedation, seizures, coma, etc. that may be confused with anesthetic effects at the end of surgery or in the PACU. Avoid agents that further elevate ICP (Desflurane, succinylcholine, hypoventilation, unnecessary oropharyngeal suctioning, fentanyl).
Effects of Anesthesia on Hyponatremia– Anesthesia/surgery causes SIADH to occur afterwards over several days, causing hyponatremia days after anesthesia
Complications- 44% increased risk of death within 30 days of surgery, risk of major coronary event, pneumonia, and wound infections double
Treatment pre-op: Depends on the cause and determining this requires a full workup to divide hyponatremia into subtypes that respond to different and sometimes exactly the opposite treatment. Simply giving IV sodium chloride treating the serum Na without evaluating the urine sodium concentration and state of hydration can prove disastrous. Unless the surgery is emergent due to a life threatening situation, Na should be corrected to at least 125 for urgent surgery or 129 for elective surgery or until the hyponatremia associated severe symptoms of hyponatremia (confusion, ataxia, seizures, obtundation, coma, respiratory depression) have resolved. Serum osmolality may be helpful in differentiating causes and assisting in treatment.
Treatment intraop: If hypertonic sodium chloride is being given as an infusion preoperatively, continue this intraoperatively. In general, use 0.9% sodium chloride (normal saline) with 154 mEq/l sodium instead of LR (Lactated Ringers) with 130 mEq/l sodium.
Treatment postoperatively: Hyponatremia may worsen after surgery due to SIAD and the time course may be over several days. De novo hyponatremia may occur after surgery.