I know your pedigreeeee!

[Dentalicous1234]

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okay kidding, i don't and pedigrees make me think of that song

I actually have a question on pedigrees please help😳
Destroyer #102: I get that it's not Xlinked but why is it dominant and not recessive?

Basically how do you tell the difference (fast!) b/t autosomal recessive and autosomal dominant inheritance in a pedigree?

I found this http://www.uic.edu/classes/bms/bms655/lesson3.html
outlining autosomal dominant as:
"Each affected individual has an affected parent; there is no skipping of generations. Males and females are equally likely to be affected. About 1/2 of the offspring of an affected individual are affected (the recurrence risk is 1/2). Normal siblings (II-3) of affected individuals have all normal offspring."

 

[jlee1986]

okay kidding, i don't and pedigrees make me think of that song

I actually have a question on pedigrees please help😳
Destroyer #102: I get that it's not Xlinked but why is it dominant and not recessive?

Basically how do you tell the difference (fast!) b/t autosomal recessive and autosomal dominant inheritance in a pedigree?

I found this http://www.uic.edu/classes/bms/bms655/lesson3.html
outlining autosomal dominant as:
"Each affected individual has an affected parent; there is no skipping of generations. Males and females are equally likely to be affected. About 1/2 of the offspring of an affected individual are affected (the recurrence risk is 1/2). Normal siblings (II-3) of affected individuals have all normal offspring."

that explanation basically tells you how to tell the difference: if there is an affected individual in every generation (black circle or square in every generation), the disease will most likely be autosomal dominant. if you try a punnett square for several generations, you'll be able to track the disease. i hope this helps!

 

[Dentalicous1234]

thank you! but wait is that all we use? autosomal recessive pedigrees dont' always show a skipped generation. I think that's what's throwing me off because for example in the kaplan book it shows an example of the pedigree for albinism and it doesn't show a skip, it looks so much like the this one for autosomal dominant. What's another more sure way to tell the difference?