F fataliz Full Member 7+ Year Member Mar 26, 2015 #1 Advertisement - Members don't see this ad Hi, i'm getting 2 conflicting information from texts on whether this is a nucleophilic addition or substitution. Kaplan : Substitution EK : Addition Seems like its a substitution to me since the oxygen leaves. comments?
Advertisement - Members don't see this ad Hi, i'm getting 2 conflicting information from texts on whether this is a nucleophilic addition or substitution. Kaplan : Substitution EK : Addition Seems like its a substitution to me since the oxygen leaves. comments?
Cawolf PGY-2 10+ Year Member Mar 26, 2015 #2 It's not substitution, those are Sn1, SN2, EAS, etc. This is the case of nucleophilic addition (amine to carbonyl) followed by elimination (or condensation if you prefer). Upvote 0 Downvote
It's not substitution, those are Sn1, SN2, EAS, etc. This is the case of nucleophilic addition (amine to carbonyl) followed by elimination (or condensation if you prefer).
