I briefly did some research and here is what I found. Anyone that knows more info, feel free to correct or add.
So the MHC-anitgen complex activates the T-cell to secrete cytokines (these can attract macrophages, neutrophiles, lymphocytes...)
+selection (occurs in thymus cortex) selects for T cells the are capable of interacting with the MHC.
And depending on which type of MHC (I or II) it interacts with-> this helps with the differentiation of these T cells. When it passes +selection, -selection starts to check the T-cell.
-selection (occurs in thymus medulla) removes T cells that are capable of interacting TOO STRONG with the MHC. If it is too strong, the T cell can induce autoimmune disease-> so the cell undergoes apoptosis.
After +&- selection, the T-cell will be released from the thymus to the lymph node as a mature T-cell.
I think it'll just be important to understand the differentiations of T cells (CD4/CD8) and that the +/- selection is almost like a checkpoint for maturation of T-cells. Also the movement. Thymus Cortex->thymus medulla->lymph node.
Was this a passage question? If not, it would be appreciated if I could take a look at the question.
