immuno question help ??

[chipotle]

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62) Delayed-type hypersensitivity is characterized by the accumulation of lymphocytes to the area of infection; These sensitized lymphocytes released what chemofactors to attract other inflammators ;
a) Leukotrienes
b) Lymphokines
c) Histamine
d) Haptens
What would be the answer ?😕😕

 

[crazy_sherm]

Type IV delayed hypersensitivity is t-cell mediated, so the correct answer should be B. Lymphokines.

 

[chipotle]

Type IV delayed hypersensitivity is t-cell mediated, so the correct answer should be B. Lymphokines.

I understand that Lymphokines have many roles, including the attraction of other immune cells, like macrophages and other lymphocytes, to an infected site and their subsequent activation prepare them to attack the invaders. Cirulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is require
But i read that leukotriene is a chemotactic factor for macrophages too ..read this link as well from wikipeadia.
http://wiki.answers.com/Q/What_are_leukotrienes
doesnt clear the confusion...please explain !😕
Thanks

 

[crazy_sherm]

Leukotrienes are primarily released by proinflammatory cells such as mast cells and eosinophils to attract other leukocytes (macrophages, neutrophils, etc.) as well as having a powerful effect in bronchoconstriction, they also increase vascular permeability. It is about 1,000 times stronger than histamine. A common example of this type of release is seen in asthma. Leukotrienes mediate many of the pathophysiologic processes associated with asthma, including microvascular leakage, bronchoconstriction, and eosinophil recruitment into the airways.

Lymphokines on the otherhand are released by lymphocytes, which is what the question is asking, and thus, the best answer for this question.

 

[chipotle]

Leukotrienes are primarily released by proinflammatory cells such as mast cells and eosinophils to attract other leukocytes (macrophages, neutrophils, etc.) as well as having a powerful effect in bronchoconstriction, they also increase vascular permeability. It is about 1,000 times stronger than histamine. A common example of this type of release is seen in asthma. Leukotrienes mediate many of the pathophysiologic processes associated with asthma, including microvascular leakage, bronchoconstriction, and eosinophil recruitment into the airways.

Lymphokines on the otherhand are released by lymphocytes, which is what the question is asking, and thus, the best answer for this question.

Thanks for clearing my doubt regarding the question. Now I know the best answer is lymphokine but the question i have in my mind for now is does leukotriene play a role in type 4 reactions also??....coz u mentioned asthma which is type 1 hypersenstivity !

 

[vijaggi]

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[niti12]

acceptable plastic that can be used for steam sterilization or autoclave is
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