Immunology Q

[Kluver_Bucy]

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Could an increase in IL2 by the Th1 response decrease type 2 hypersensitiivies such as Grave's Disease? Can an increase in IL4 by Th2 response decrease type 4 hypersensitivities such as multiple sclerosis? Someone told this today but I couldn't figure out how. Thanks for your help.

 

[idq1i]

IL 10 is generally associated with shutting off Th1 response (your IV HS)
IL 12 is generally associated with shutting off Th2 response (your II/III HS)

IL4 is a B cell proliferation cytokine. It also promotes IgE/IgG1 switching
IL2 is a pro-T cell proliferation cytokine, needed by T cells for completion of maturation

 

[HiddenTruth]

IL 10 is generally associated with shutting off Th1 response (your IV HS)
IL 12 is generally associated with shutting off Th2 response (your II/III HS)

IL4 is a B cell proliferation cytokine. It also promotes IgE/IgG1 switching
IL2 is a pro-T cell proliferation cytokine, needed by T cells for completion of maturation

With all due respect to your vast knowledge in medicine, I have to disagree. While, IL-12 promotes differentiation and promotion of TH1 cell proliferation, I believe IFN-y is the primary CK that inhibits TH2 response and proliferation of those cells.

 

[idq1i]

With all due respect to your vast knowledge in medicine, I have to disagree. While, IL-12 promotes differentiation and promotion of TH1 cell proliferation, I believe IFN-y is the primary CK that inhibits TH2 response and proliferation of those cells.

Sarcasm notwithstanding, I agree, IFNg is there too.

IL12 is the primary cytokine in the cascade. It induces NK cells to secrete IFNg, which in turn allows CD4 cells to secrete more IFNg, IL2 and TGF. In other words, not much IFN is made without IL12 participation. No IL12 -> no NK IFNg -> no Th1 -> no Th1 IFNg to shut off Th2

 

[HiddenTruth]

Sarcasm notwithstanding, I agree, IFNg is there too.

IL12 is the primary cytokine in the cascade. It induces NK cells to secrete IFNg, which in turn allows CD4 cells to secrete more IFNg, IL2 and TGF. In other words, not much IFN is made without IL12 participation.

i can almost bet that in a testing situation, ifn-y would be the correct choice, as it is the immediate CK that would inhibit TH2 response.

 

[idq1i]

i can almost bet that in a testing situation, ifn-y would be the correct choice, as it is the immediate CK that would inhibit TH2 response.

Yeah, you are right. I don't expect a question which has both IL12 and IFNg as answer choices.

I guess I'll find out tomorrow

 

[HiddenTruth]

Yeah, you are right. I don't expect a question which has both IL12 and IFNg as answer choices.

I guess I'll find out tomorrow

Good luck! I am sure you'll do well.