This is debated a lot at SDN. The community seems pretty divided on it actually. What I've surmised is that it depends on your ability to explain your reasoning and what evidence you have to back it up. For example, if you take Bio 1 at a CC and claim you did so for something like financial reasons, but you have a low Bio score on the MCAT and you did poorly in your advanced Bio classes then it doesn't look good for you. In this example, it looks like you were a poor biology student and simply wanted an easy A. If however, you scored high in your MCAT bio and have all A's in your advanced bio courses, it seems likely that your CC Bio 1 won't be given a second thought.