Interesting Fact From UWORLD -

[HelpPleaseMD]

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Under the explanation for treatments of osteoporosis UWORLD lists bisphosphonates, SERMS, estrogen, calcitonin, but also PTH.

Anyone know why PTH is anabolic in osteoporosis patients? Is it because the stimulation of osteoclast also stimulate osteoblast? 😵

 

[Phloston]

Under the explanation for treatments of osteoporosis UWORLD lists bisphosphonates, SERMS, estrogen, calcitonin, but also PTH.

Anyone know why PTH is anabolic in osteoporosis patients? Is it because the stimulation of osteoclast also stimulate osteoblast? 😵

That's a good question.

You know how PTH upregulates osteoblastic activity, leading to osteoclastic activity?

Well there's a drug called teriparatide, which is a PTH analogue used in osteoporosis. The idea is that, given appropriate dosing/frequency/etc., the osteoblastic mechanism is upregulated and then the drug is removed before the osteoclastic activity can predominate.

 

[HelpPleaseMD]

That's a good question.

You know how PTH upregulates osteoblastic activity, leading to osteoclastic activity?

Well there's a drug called teriparatide, which is a PTH analogue used in osteoporosis. The idea is that, given appropriate dosing/frequency/etc., the osteoblastic mechanism is upregulated and then the drug is removed before the osteoclastic activity can predominate.

Thanks. Yea that makes sense.

 

[thinkenergy]

In short, it depends on how AAs you use. PTH is 84-AA polypeptide w/ its N-terminus having bone & kidney actions and its C-terminus having bone action along w/ prohormone processing. If you use PTH (3-34 AA) or (7-34 AA), you will be breaking down bone, but if you use PTH (1-34 AA, ie teriparatide), you are actually preventing bone breakdown. It is kind of weird.

 

[sapg21]

That's a good question.

You know how PTH upregulates osteoblastic activity, leading to osteoclastic activity?

Well there's a drug called teriparatide, which is a PTH analogue used in osteoporosis. The idea is that, given appropriate dosing/frequency/etc., the osteoblastic mechanism is upregulated and then the drug is removed before the osteoclastic activity can predominate.

yeah i think the pulsatile bit is key...its in fa11 pg379

 

[Phloston]

yeah i think the pulsatile bit is key...its in fa11 pg379

P.379, at least of the 2012 FA, is about RBCs. Regardless, a good tidbit to have down.

 

[Aclamity]

Pulsatile PTH is what you use. Actually teriparatide is a new PTH analog drug and it's actually the only drug thus far that leads to increased bone mass. It's just not that popular yet because it's so new, but I think it illustrates the point that PTH is necessary for maintaining/building bone

 

[ijn]

It's also not too popular because of the osteosarcoma risk. 😱