Assuming you're talking about this in the context of statistics/research:
Internal validity has to do with how much the research study is vulnerable to bias due to methods. So for instance an uncontrolled drug trial with no blinding would have low internal validity; a double blind RCT would have high internal validity.
External validity has to do with how applicable the study results are to the general population. For example, in a study looking at management of HTN, if the participants have a relatively low rate of comorbid illnesses like DM or high cholesterol compared to the general population, the results might not be super applicable to other patients that do have more comorbidities.