Step I Is 11-deoxycorticosterone a weak, or a potent, aldosterone analog?

[Money Moniker]

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In Pathoma it is referred to as weak compared to aldosterone, but in First Aid 11-hydroxylase deficiency is said to cause hypertension and hypokalemia. Is this because DOCA is in fact more potent than aldosterone, or simply that it is made in higher quantities in CAH patients due to less cortisol negative feedback than aldosterone would be in normal people? Ie, it is weaker, but made in greater amounts?

 

[Pepe18]

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[Rahas]

Weak, but its controlled differently, which is why in CAH you get an excessive amounts. Synthesis is dependent on ACTH (which is high) and independent of the RAA axis (A-II activates aldosterone synthase, which is downstream), so essentially it is unregulated.