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Is B-cell always activated by the T-helper cell?

Discussion in 'MCAT Study Question Q&A' started by Deepa100, Jun 17, 2008.

  1. Deepa100

    Deepa100 Junior Member 10+ Year Member

    Aug 24, 2006
    or can it act on its own?
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  3. HawkeyePostOp

    HawkeyePostOp the fort at sidewalk 5+ Year Member

    I'm confused by this too. Books say yes, that B cells can sometimes bind to an antigen by themselves and become activated. B cells are usually stimulated by T-helper cells that release cytokines, but can also be activated by interleukins secreted by macrophages.

    peer review, anyone?
  4. ThePandaFactor

    ThePandaFactor 2+ Year Member

    Jun 18, 2008
    Some antigens can activate B cells without the need for T cells, but mostly the T cell is involved.
  5. chreesteene

    chreesteene 5+ Year Member

    May 23, 2007
    i've always thought that B cells can be activated by antigens on their own (and start clonal selection, etc) but they work MUCH MUCH better when also induced by IL-2 (?) released by Helper Ts. Please correct me if I'm wrong...

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