Is it NADH or Pyruvate that requires the additional ATP for transfer to Mitochondrial matrix?

[PocketRocket]

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Im using feralis notes and cliffs for bio review and I noticed that the Feralis states:
"Difference because prokaryotes have no mitochondria so they (unlike eukaryotes) don’t need to transfer pyruvate into the mitochondrial matrix (which is done via active transport thus costing ATP), they use cell membrane for respiration"

While Cliff's states:
"However, this number is reduced to 36 because the 2 NADH that are produced in the cytoplasm during glycolysis must be transported into the mitochondria for oxidative phosphorylation."

What am I missing here?

 

[FeralisExtremum]

Good catch! It is the NADH and not the pyruvate that carries the ATP cost. I'll fix that for the next version of the notes.

 

[PocketRocket]

Haha the man him self, thank you!

 

[ns718]

Ohhh Feralis is a man. I wasn't sure until now 🙂

 

[99dmg]

Pyruvate is still transferred to the mitochondrial matrix via active transport though, so both cost the cell energy to transport

 

[FeralisExtremum]

Pyruvate is still transferred to the mitochondrial matrix via active transport though, so both cost the cell energy to transport

This is also true. Pyruvate uses secondary active transport via symport with protons, so it requires energy, but doesn't directly use ATP. Hopefully more detail than you'll ever need to know for DAT.

 

[PocketRocket]

Prefect, makes sense