Ischemia of Brain

[DrTacoElf]

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What areas of the brain are affected first by ischemia. I had this written down somewhere but I can't seem to locate it.

I know for kidney its straight portion of PCT and thick ascending limb of the loop of henle (Goljan audio)

Liver would be zone 3 near the central vein.

Thanks!

 

[username456789]

What areas of the brain are affected first by ischemia. I had this written down somewhere but I can't seem to locate it.

I know for kidney its straight portion of PCT and thick ascending limb of the loop of henle (Goljan audio)

Liver would be zone 3 near the central vein.

Thanks!

As a general rule, I think pyramidal neurons are most sensitive to ischemia . . . hippocampus, cortex, etc. I assume you're talking about global hypoxia, and not ischemia due to any specific vessel blockage.

 

[DrTacoElf]

Yeah global hypoxia is what I was talking about.

You are right pyramidal neurons of hippocampus --> short term memory loss

There was one other area also I think....and specific layers mentioned when I saw it written before....

 

[username456789]

Yeah global hypoxia is what I was talking about.

You are right pyramidal neurons of hippocampus --> short term memory loss

There was one other area also I think....and specific layers mentioned when I saw it written before....

There are specific layers in the cortex . . . 5 comes to mind, along with . . . something else? It might be in HY Neuro, I'll try to dig that up if no one else comes along to the rescue here.

 

[creamyBokah]

It's the Purkinje cells in the cerebellum and layers 3, 5 and 6 of the cortex ... pg 6 of RR Path 3rd edition ... I remembered this off the top of my head but just looked it up to make sure to give you the right info ... not bragging just attesting to the power of Anki + repetition (use it!!).

I actually remember it from BRS Neuroanatomy or HY Neuro (not sure which book I memorized both) but those books don't mention anything about the central vein or renal stuff (not that it's wrong just noting that Goljan is the only place that mentions it all), just the layers of the cortex that are sensitive to ischemia.

 

[creamyBokah]

This is starting to dislodge some memories from my head ... just remembered Sommer's sector (CA1) of the Hippocampus is sensitive too.

 

[turkeyjerky]

Yeah global hypoxia is what I was talking about.

You are right pyramidal neurons of hippocampus --> short term memory loss

There was one other area also I think....and specific layers mentioned when I saw it written before....

I think you're looking for purkenje cells of the cerebellum, as I recall, and layers 3,5, and 6 of the cerebral cortex; bonus points if you know what those layers are.

 

[Domenech]

Don't forget the watershed areas. Anterior and Middle Cerebral arteries and I think it also applies to Superior Cerebellar and (either Posterior Inferior or Anterior Inferior) Cerebellar Artery.

 

[DrTacoElf]

Don't forget the watershed areas. Anterior and Middle Cerebral arteries and I think it also applies to Superior Cerebellar and (either Posterior Inferior or Anterior Inferior) Cerebellar Artery.

Yeah with the anterior and middle cerebral watershed stroke you will get proximal arm and leg weakness with distal strength preserved = MAN IN A BARREL PRESENTATION 😛

Not sure about Cerebellar, will get to you guys on that....

 

[2001bmw330xi]

just did a uWorld question two days ago that explained this very fact!