J&J on the move, new Antibiotic approved

[Epic]

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http://www.jnj.com/news/jnj_news/20071015_104421.htm;jsessionid=CDH2RQFMYT0PUCQPCAOWU3YKB2IIWTT1

Doribax has been approved by the FDA. Can you named 2 other drugs in this class? What do you think the advantages of this drug is over the other two?

 

[KARM12]

http://www.jnj.com/news/jnj_news/20071015_104421.htm;jsessionid=CDH2RQFMYT0PUCQPCAOWU3YKB2IIWTT1

Doribax has been approved by the FDA. Can you named 2 other drugs in this class? What do you think the advantages of this drug is over the other two?

Ertapenem, Imipenem. Advantages? Not sure on that.

 

[Epic]

Ertapenem, Imipenem. Advantages? Not sure on that.

ehhh...one of em doesn't belng in the group...

 

[SpirivaSunrise]

Pseudomonas aeruginosa coverage

doripenem > meropenem

 

[KARM12]

Okay ertapenem doesn't cover pseudomonas... imipenem and meropenem.

 

[Epic]

Pseudomonas aeruginosa coverage

doripenem > meropenem

how do you know..

 

[SpirivaSunrise]

how do you know..

How do I know...or why do I know?

 

[KARM12]

how do you know..

The drug rep told me so!

 

[Epic]

How do I know...or why do I know?

how can we believe that? And how does that translate to clinical outcomes?

 

[Epic]

The drug rep told me so!

Oh.. gospel has been spoken then..

 

[SpirivaSunrise]

We'll see if the in vitro studies translate to real life...it's fast-tracked for HAP

 

[Epic]

I'm so sad...I try to edumacate you young folks..and some old farts.. and newbies come on board and think I'm loud mouthed.. wait, they're right..

 

[Epic]

We'll see if the in vitro studies translate to real life...it's fast-tracked for HAP

that's not an answer..

 

[SpirivaSunrise]

that's not an answer..

I didn't say it was

 

[KARM12]

It says it has activity against c. diff....but wouldn't you be worried about it causing c. diff since it is so broad spectrum?

 

[Epic]

It says it has activity against c. diff....but wouldn't you be worried about it causing c. diff since it is so broad spectrum?

You asking me?

Why don't you tell me...

 

[KARM12]

I am actually not sure....that is what I would think. You are killing off a lot of that gut bacteria.

 

[Epic]

I am actually not sure....that is what I would think.

C.Diff...that would be a good topic for you to delve into...

 

[PharmDstudent]

It's just another rambling clinical thread 🙄.

 

[Epic]

I didn't say it was

I want answers dang it!

 

[Epic]

It's just another rambling clinical thread 🙄.

you love it.

 

[Epic]

I am actually not sure....that is what I would think. You are killing off a lot of that gut bacteria.

but we already have with ertabpenm, imipenem, and meropenem...

 

[KARM12]

C.Diff...that would be a good topic for you to delve into...

I know all about C. Diff...I could smell it a mile away. Everyone at the VA had it. Not good.

 

[Epic]

I know all about C. Diff...I could smell it a mile away. Everyone at the VA had it. Not good.

Oh is that right.... so what's caused all those C.Diff outbreak recently

 

[KARM12]

but we already have with ertabpenm, imipenem, and meropenem...

Any with pretty much any broad spectrum antibiotic.

 

[KARM12]

Oh is that right.... so what's caused all those C.Diff outbreak recently

Dirty hands

 

[Epic]

Any with pretty much any broad spectrum antibiotic.

you mean to tell me broad spectrum abx is the only culprit?

 

[Epic]

Dirty hands

You're scrambling.. yes, dirty hands had a lot to do with it... gather your thoughts and organize it..

 

[KARM12]

you mean to tell me broad spectrum abx is the only culprit?

No...but it is a factor.

 

[KARM12]

You're scrambling.. yes, dirty hands had a lot to do with it... gather your thoughts and organize it..

I thought I finished my rotations....

C. Diff has spores that are stable on surfaces...which is why proper contact precautions and disinfection of the patient room are necessary.

 

[Epic]

This article is too large for me to load here..

If you have a subscription to CID...then more better... but here is a good read.

Emergence of Fluoroquinolones as the Predominant Risk Factor for Clostridium ...
Jacques Pépin; Nathalie Saheb; Marie-Andrée Coulombe; Marie-Eve Alary; et al
Clinical Infectious Diseases; Nov 1, 2005; 41, 9; Research Library

 

[Epic]

I thought I finished my rotations....

You are never finished...

 

[PharmDstudent]

you love it.

Honestly, there are other forms of torture that are more enjoyable, my epilator for instance.

 

[SpirivaSunrise]

how can we believe that? And how does that translate to clinical outcomes?

It's a carbapenem...broadest spectrum spectrum beta-lactams...good DOC for gram-neg when resistance is an issue. If it really is more potent than Meropenem, we're probably talking MIC's of 4 rather than 8+. Seems like it's main place will be with serious nosocomial infections where resistance is an issue.

 

[Epic]

It's a carbapenem...broadest spectrum spectrum beta-lactams...good DOC for gram-neg when resistance is an issue. If it really is more potent than Meropenem, we're probably talking MIC's of 4 rather than 8+. Seems like it's main place will be with serious nosocomial infections where resistance is an issue.

Why not keep using Imipenem or Meropenem

 

[Epic]

Honestly, there are other forms of torture that are more enjoyable, my epilator for instance.

I'm glad I enjoy learning...

nm

 

[SpirivaSunrise]

Why not keep using Imipenem or Meropenem

We should

 

[Epic]

We should

they why add Doripenem to the formulary?

 

[SpirivaSunrise]

they why add Doripenem to the formulary?

Depends...are there issues with resistance in this imaginary hospital?

 

[SpirivaSunrise]

You're distracting...I'm supposed to be working

 

[PharmDstudent]

nm

Learning is different from being harassed by the clinical gods. I'm not scrambling for scraps.

 

[Epic]

Depends...are there issues with resistance in this imaginary hospital?

I haven't come across too many hospitals with Carbapenem resistance issues... I know one in CT who's having issues..

 

[Epic]

Learning is different from being harassed by the clinical gods. I'm not scrambling for scraps.

YES! He called me the clinical god!!!! oh ..she.

 

[WVUPharm2007]

Rather than learn everything about ID, I'm going to invent the antibiotic that kills everything and is impervious to resistance. That seems easier.

 

[SpirivaSunrise]

And I don't like to bring up cost when we're talking clinical outcomes...but how much are we talking about?

 

[KARM12]

Sorry...work called me and told me I didn't have to come in today...so I went back to bed.... Where were we?

 

[Epic]

And I don't like to bring up cost when we're talking clinical outcomes...but how much are we talking about?

blasphemy....

 

[Epic]

Sorry...work called me and told me I didn't have to come in today...so I went back to bed.... Where were we?

"we" are getting ready for a conference call...

 

[SpirivaSunrise]

blasphemy....

Isn't it? Always gotta look at the bottom line...

 

[SpirivaSunrise]

"we" are getting ready for a conference call...

You wouldn't happen to be one of those people that rolls their eyes and mocks the other people while their talking would you? 🙄