Krebs cycle during anaerobic metabolism?

[Monkeymaniac]

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Electron transport chain definitely would require oxygen, I can see that. But it seems that Krebs cycle doesn't directly use oxygen, although its products are oxidized by oxygen in ETC. So can the Krebs cycle happen in the absence of oxygen? EK states that pyruvate from glycolysis is transported into mitochondria matrix only in the presence of oxygen, but I wasn't sure if this is what's preventing the cycle in aneaerobic condition. Thanks in advance!

 

[bxadook]

For anaerobic respiration, the pyruvate generated from glycolysis is reduced to lactate to regenerate NAD+ for another round of glycolysis.

Another round of glycolysis would generate two ATP compared to the 1 ATP (1 GTP = 1 ATP) formed by the Kreb's cycle during anaerobic respiration. Therefore I think the cell would be at an advantage to stick with glycolysis.

 

[IntelInside]

It will effectively shut down because if it didnt, I would have tons of NaDH and Fadh2 build up which would effectively shut down even glycolysis because the reduced coenzyme Nad+ is required for glycolysis. That is how I see it

 

[Monkeymaniac]

That makses sense. Thanks guys!

 

[bxadook]

Ahh that is also true and a very good point..👍

 

[Paseo Del Norte]

It will effectively shut down because if it didnt, I would have tons of NaDH and Fadh2 build up which would effectively shut down even glycolysis because the reduced coenzyme Nad+ is required for glycolysis. That is how I see it

You are correct that it effectively shuts down. However, if I'm not mistaken, NADH is oxidised by the way of reducing pyruvate in lactic acid fermentation. This ensures NAD+ is available for glycolysis.

 

[Charles_Carmichael]

You are correct that it effectively shuts down. However, if I'm not mistaken, NADH is oxidised by the way of reducing pyruvate in lactic acid fermentation. This ensures NAD+ is available for glycolysis.

👍

 

[IntelInside]

You are correct that it effectively shuts down. However, if I'm not mistaken, NADH is oxidised by the way of reducing pyruvate in lactic acid fermentation. This ensures NAD+ is available for glycolysis.

yes you are correct i was using it in the sense that if the cell keeps trying to go through aerobic respiration that there will be none. fermentation will regenerate NAD+ in anearobic conditions