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ligand and enzyme

Discussion in 'DAT Discussions' started by pistolpete007, Jun 5, 2008.

  1. pistolpete007

    pistolpete007 2+ Year Member

    May 18, 2008
    destroyer number 276.....consider the insulin receptor. This receptor allos insulin to bind and triggers a conformational change within the receptor subunits. insulin can be acting as an:
    a. enzyme
    b ligand
    c mutagen
    d domain
    e receptor

    the answer is B because of the conformational change but dont enzymes go under conformational change upon binding so why cant it be A...whats the diff b/w the two?
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  3. Sama951

    Sama951 2+ Year Member

    Apr 14, 2008
    yeah enzymes undergo conformational changes when they bind a substrate but that's not what the question's asking. It's asking you what you'd classify INSULIN itself as when it's binding to a RECEPTOR. Ligands bind to receptors - and in this case it triggers a conformational change somewhere along the receptor which causes other stuff to happen.
  4. DCRedskinsRule

    DCRedskinsRule 7+ Year Member

    May 27, 2008
    Also, a simple way to keep this straight is that in this context, the term "ligand" is interchangeable with "substrate" so that makes insulin VERY different from the enzyme. Hope that helps!:)
  5. TempleDMDKrazd

    TempleDMDKrazd 7+ Year Member

    Mar 10, 2008
    the question is asking about "insulin" in "what is which it causes a conformational change in the insulin receptor (the enzyme)"...therefore insulin is the ligand...
  6. Sea of ASH

    Sea of ASH 2+ Year Member

    Sep 15, 2007
    good point :thumbup:

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