Vanc is far cheaper and gets your MRSA ancef may not. Ioban, chlorhexidine, pt selection, faster surgeries, MRSA swab with decolonization protocol, cauterizing bleeders, minimizing tissue handling, preop BG/HbA1C, Irrigation, changing top gloves, reducing in/out of room goes a long way.
Tyrex study: n=6983 implants; control=42 infections 1.2%, Tyrex=25 infections 0.7%; I'd hardly say thats substantial 1.2 vs 0.7%, thats where they get the 40% reduction from. When you look at the numbers you realize its 1% rounding up or down. The tyrex pouches only last like 90 days on the shelf as well I believe.