Location of B cells, Tcells (all types)

[imapremed]

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PLEASE HELP WITH THIS SO BOTHERSOME!

I know B cells are located in the spleen and lymph nodes and mature there

Can B cells be found outside of this? or is it only the plasma cells that can be found outside of this?

I know T cells mature in the thymus and suppresor T cells are located there to suppress self-reactive t cells from fully maturing

Know, where are helper t cells located and where are cytotoxic t cells located?

And im guessing natural killer cells can be located throughout the body since they kill cells that fail to show a regular MHC 1 (no anitgen on there).

 

[imapremed]

Bump. Anyone?

 

[gunj122]

B cells arise in the bone marrow and mature to a certain extent there. i believe they are then sent out in circulation, through both blood and lymph. in the lymph nodes, they are further matured and activated in response to antigen presenting cells (APCs). so to answer your question, i think B cells are not restricted to the spleen or lymph nodes. they circulate in our blood and lymph systems and are matured into plasma cells when they come into contact with an APC or sometimes it can act as an APC, but this is more rare.

Both T-helper and T-cyto circulate in the blood once they are fully matured in the thymus. They aren't separated by barriers or anything.

NK cells also circulate in the blood and are activated in response to abnormal MHC display.

 

[hvairline]

B cells arise in the bone marrow and mature to a certain extent there. i believe they are then sent out in circulation, through both blood and lymph. in the lymph nodes, they are further matured and activated in response to antigen presenting cells (APCs). so to answer your question, i think B cells are not restricted to the spleen or lymph nodes. they circulate in our blood and lymph systems and are matured into plasma cells when they come into contact with an APC or sometimes it can act as an APC, but this is more rare.

Both T-helper and T-cyto circulate in the blood once they are fully matured in the thymus. They aren't separated by barriers or anything.

NK cells also circulate in the blood and are activated in response to abnormal MHC display.

I think you may be confusing B cells with T cells with respect to antigen presentation. You are right, B cells tend to travel throughout the body (blood,interstitial fluid etc..) but when they encounter an antigen with the correct epitope , B cell Receptors on their cell surface bind directly to that antigen and become activated. T cells are activated when they come in contact with antigen presenting cells (e.x. Dendritic Cells (DC)). The CD8+ and CD4+ T cells then differentiate into cytotoxic cells and helper t cells respectively. The Helper T cells then further interact with the previously activated B cells by secreting cytokines and the B cells then differentiate into plasmocytes which produce antibodies. B cells do not need APCs to become activated. Correct me if I'm wrong.

 

[gunj122]

I think you may be confusing B cells with T cells with respect to antigen presentation. You are right, B cells tend to travel throughout the body (blood,interstitial fluid etc..) but when they encounter an antigen with the correct epitope , B cell Receptors on their cell surface bind directly to that antigen and become activated. T cells are activated when they come in contact with antigen presenting cells (e.x. Dendritic Cells (DC)). The CD8+ and CD4+ T cells then differentiate into cytotoxic cells and helper t cells respectively. The Helper T cells then further interact with the previously activated B cells by secreting cytokines and the B cells then differentiate into plasmocytes which produce antibodies. B cells do not need APCs to become activated. Correct me if I'm wrong.

oh yea you're right. i used the word APC too loosely here. i meant to say B-cells are activated by T-helper cells, not APCs.

 

[imapremed]

oh yea you're right. i used the word APC too loosely here. i meant to say B-cells are activated by T-helper cells, not APCs.

thanks dude. and also the poster above.