Does this just make it so chromatin can unfold easier? 😕
Lysine Ubiquitination
- Thread starter samsorz
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Ubiquitination generally targets proteins for degradation (most of the time on lysines).
As for chromatin unfolding, I don't have any first-hand knowledge of it happening, but it very well could. In general, acetylation of histones (neutralization of the lysine positive charged residue) causes the nucleosome to unravel--this makes chromatin become more accessible. Methylation of histone lysines SOMETIMES has a negative affect on chromatin unfolding.
I think this is how it goes.
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As stated, if ubiquitination is mentioned on the MCAT its probably going to be in reference to general protein degradation. There are other functions of protein ubiquitination that you can look up if your interested.
Histone ubiquitination has been associated with transcriptional activation and polar body formation. However, I don't think there is a general consensus on the function(s) of histone ubiquitination. If your really interested You can do a pubmed search and read a review article on the topic 😉 .
Histone ubiquitination has been associated with transcriptional activation and polar body formation. However, I don't think there is a general consensus on the function(s) of histone ubiquitination. If your really interested You can do a pubmed search and read a review article on the topic 😉 .
