I was reviewing the interview feedback for OSU and I found a question that i dont know the answer to:
why is the Avian flu more prevalent in Asia that the US?
I think it has to do with the access to medical attention and the living environment. There are a lot of small rural towns/villages where the people are living in very close proximity to chickens, duck, and other wild fowl...especially the migratory fowl that are suspected of spreading the disease.
any more input? I really like this thread its really helping me prepare for my interviews. THANKS FOR ALL THE FEEDBACK GUYS!!
I apologize in advance if this gets long. I'm an Avian Biology major--I love talking about the chicken.
1. First, I'll explain the microbiology behind Avian Influenza. Be sure to point out in your interview that H5N1 (and some H7 strains) is the zoonotic form of the virus; all other forms are a threat to modern poultry rearing, but not to humans. H5N1 refers to the two types of proteins on the envelope of the virus that our immune system recognizes and uses to mount its defensive attack against the virus. Most waterfowl and other wildlife harbor some form of avian influenza virus, but not a pathogenic form. How does the virus mutate from a non-pathogenic/non-zoonotic form (say, H1N2) to the infamous H5N1? It's not easy. The only sure way they've found so far is this: a vector species--the pig--must be concomitantly infected with a human strain of influenza as well as an avian strain of influenza. (The pig is the vector because it's one of the few species that
can be infected with both avian and human viruses.) The two viruses exchange DNA for their surface proteins inside the pig's cell and BAM!--H5N1. Then the pig sneezes on its human caretaker and he ends up in the biohazard ward at the local hospital. Now, given the large variety of surface proteins, the size of each virus's genome, and the liklihood of the pig being infected with both human
and avian influenza simultaneously, it's no wonder it makes the news when a human is infected with H5N1.
2. If they ask you this question in your interview, it'll help to emphasize the differences in poultry production in the US vs. Asia. You're absolutely right--in Asia, people are living in very proximity with animals. In addition, they're rearing pigs and chickens in very close proximity with each other. I'm not sure about this, but I imagine they would also be close to ducks asl well, which--as you recall--are great carriers for non-zoonotic avian influenza (like H1N2 or something). This creates the perfect storm for the situation described in part one. In contrast, American chickens are reared in enclosed houses with no exposure to waterfowl or wild birds, and would certainly never be around a pig. While there is the possibility of infecting a flock of poultry by trudging through waterfowl feces on your way to the chicken house, good biosecurity requires that you change your shoes, your clothes, and maybe even shower before you enter a new flock's house. They don't take this kind of precaution in Asia.
3.
Additional Information:
--Two types of AI exist in poultry medicine: low-pathogenic (LPAI) and high-pathogenic (HPAI; only H5's and H7's). The USDA prohibits the use of H5 and H7 vaccines in poultry. This doesn't really matter because if a chicken is infected with HPAI, it will die within 10-15 days. Although LPAI isn't necessarily fatal, it and HPAI are both reportable--you have to tell the government if you think your flock has AI.
--The cat has been recently recognized as a potential vector for the spread of AI, but this mode of transmission has not yet been confirmed.
--It is important to note that humans have been infected through direct contact with live, infected birds--not thought handling, cooking, or eating poultry meat. This mode of transmission has also not yet been confirmed.
I know that's a lot of information, but just remember: H5N1, pigs, and biosecurity.
Hope that helps. Good luck on your interviews!
BTW, where did you find your interview questions? I haven't been selected for an interview yet, but I'm hoping...!
-xtina