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What's with all these UCB posts all of a sudden?
Anyhow, I don't think any science major is particularly GPA friendly here, but MCB seems to have the highest concentration of pre-meds along with fewer interesting (in my opinion) classes, which would make me avoid that as a major. I haven't heard of chem bio being more difficult than MCB before, but I think the courses are more interesting. I also think the professors are a bit better for chem bio than they are for MCB.
I also suggest avoiding Vollhardt (the textbook author lemoretired was referring to). I recommend Pedersen or Bertozzi for organic (Frechet is done teaching), and Francis for any chem/chembio classes you can get with him.
So I just read this and have no freaking clue what half of you are saying.
to you go to Berkeley?
Any major in the College of Chem = not GPA friendly, trust me on that. Most of UCB is not GPA friendly, actually. Plus, don't quote me on this, but I think Chem Bio has to take Chem 120A&B with the rest of the chem majors, which, unless you're really great at the more math-intensive side of physics & chemistry, will be rough-going. Molecular Cell Biology takes the easier class (Chem 130, I believe). All in all though, I've heard good things about Integrative Biology (IB) as a pre-med major.
ETA: If you want to stick with MCB, I heard the easier emphases are CDB & immunology. Genetics and Biochem are harder.
120 A/B are more intensive than 3 A/B, but I also think the series is taught better on average. Also, groups tend to be smaller, so there's some chance you could actually end up knowing your professors. I don't think any of the science majors are GPA friendly at Cal, but in CChem, at least your classes aren't all filled up with premeds. You're also more likely to get research spots if you're in chem compared to MCB because professors aren't going to question your motives as much. MCB undergrads have a (less than awesome) reputation among the grad student population, and that can make it harder to get research positions on campus.
Are you referring to organic chemistry? Because 112 A/B is the corresponding organic chem series for chem majors, analogous to the 3 series. When I referred to 120 A/B, I meant physical chemistry, which I know is required for chemistry majors and I'm pretty sure it's required for chem bio students as well. Chem 120 A/B is a lot harder than the 130 series, but, depending on the professor, is usually better taught. As far as the science majors being GPA friendly or not, I can't comment on all of them since I don't know enough about them all. I just heard that IB is easier than MCB and MCB's easier specialties are immuno & CDB. As far as the groups being smaller, yeah, 112 series is smaller than 3, but the class still fills up the Lewis Hall lecture room. If you want your professor to know you, your only shot is office hours. Or if you had an awesome special project poster presentation while taking the 4 series and they attended the event.
As far as research, if you're going to be doing research for the chem department you're going to have to sacrifice a lot of your time doing it. I think the reason they scrutinize your motives is because they want to make sure you're serious about putting the time/effort into it. I can't speak to MCB research, but I think most people who are pre-med would rather spend their time studying to get As and preparing for the MCAT than sitting there on the bench tracking a reaction by TLC and spending hours running a column.
ETA: http://chemistry.berkeley.edu/student_info/USLI/chemistry/#core core curriculum for chem & chem bio majors. In addition to the 120 series (physical chemistry), you have to take more intensive math courses such as multi-variable calculus and linear algebra and physics for scientists and engineers (although not sure if they still do this, they used to accept the 8 series for the 7 series). It all depends on the individual. If you're more physical science/math inclined, go for it and go the college of chem route or physics or engineering. But don't pick any of these majors because you think it'll be "easier" to get As. All of these majors require hard work and are super competitive.