Memorizing essential amino acids

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usmlesuccess

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10+ Year Member
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Does anyone have some mnemonic to memorize the essential amino acids? My test is in a week, and I would appreciate any help!!! 🙂
 
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This may be a good place to say that I had two difficult amino acid questions on my exam, neither of which I knew (I made educated guesses). So I do think amino acids are high yield.
 
Some other info I've encountered:

Lysine + tryptophan are decreased in Kwashiorkor. I've had a practice question on this asking for the specific amino acid deficient in this disease, and it's either one of these. Apparently these two are found heavily in meat, and those with Kwashiorkor have protein-deficient diets based significantly on not having any meat.

Histidine, although an essential amino acid, can be synthesized by humans during periods of increased metabolic demand or growth (e.g. muscle injury, puberty). It's considered an essential amino acid based on the fact that we still need to consume it in order to achieve adequate metabolic levels, although one should be aware that it is synthesized. I've also seen a practice question on this.

Linoleic and linolenic acids are the essential fatty acids. Prostacyclins, prostaglandins, thromboxanes and leukotrienes are all synthesized from fatty acids (which you probably already know).

Also, operons associated with the synthesis of amino acids tend to demonstrate attenuation, which means transcription is terminated during the middle of transcription once sufficient amino acids have been translated. There's a negative-feedback mechanism involving a hairpin structure that terminates transcription, not translation.

And, yes, I've seen practice questions on that stuff too.
 
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This is a full list of amino acids I am aware of that are present on UWorld/NBMEs. It's actually a lot more important than people realize:

Glycine - smallest amino acid - located everywhere. Inhibitor neurotransmitter of the spinal cord. Tetanus blocks the release of glycine from the spinal cord, thats why you have really strong muscle contractions. This causes the diaphragm to lock up and the patient can't breathe anymore.

PHE, TRP, TYR - aromatic amino acids

LYS, ARG - basic amino acids

Asp - main amino acid used for reinforcement of the NMDA pathway, important in cases of gambling and addictions

CYS, MET - contain sulfur

Asparagine, Glutamine - Involved in N-bonds

Serine, Threonine, Tyrosine - involved in O-bonds. Serine is involved in the active site of many enzymes (serine proteases)

These most people know:
LEU, ISO, VAL - branched chains. All 3 handled by the same transport protein in the collecting duct of the kidney.

TYR - used to make catecholamines, melanin

TRP - used to make serotonin

Ketogenic Amino Acids - lysine and leucine. What does ketogenic mean? -> Made from and broken back into acetyl CoA, which is used to make ketones

Both Glucogenic and Ketogenic - PHE, ISO, THR, TRP