Geez...I can't remember a reference for this...I know someone has studied this extensively but I'm forgetting his name.  
Anyways, I think somewhere in this review by Jack Szostak might have a reference that can point you in the right direction...sorry, I can't give that to you right now...getting papers off campus really bites.
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15556412
A lot of Szostak's work, at least recently, have been done by Irene Chen, a Harvard MD/PhD student.