micro qs

[shafaq nomani]

---

Members don't see this ad.

vasodilation n increase vasopermeability lasting for several days in an area of iflamation, indicae which o the following?
1-thrombosis
2-released of histamine
3-hegman factor
4-formayion of granulation tissue
5-endothelial cell damage and disruption

 

[docdk]

ans 3. hegman factor activation

 

[cutedoc12]

i agree with docdk...its hageman factor activation which results in the release of bradykinin (a vasodilator and also a pain mediator)

 

[solan]

granulation tissue i guess... can you pls. post the correct answers too in your mails.... that will be very helpful. thanx

 

[solan]

i just that read somewhere that newly formed capilaries are very leaky .. so should granulation tissue not be the ans.

 

[docnc]

vasodilation n increase vasopermeability lasting for several days in an area of iflamation, indicae which o the following?
1-thrombosis
2-released of histamine[🙂]
3-hegman factor
4-formayion of granulation tissue
5-endothelial cell damage and disruption

Vasodilation is the result of factors released by platelets and other cells. The main factor involved in causing vasodilation is histamine . Histamine also causes blood vessels to become porous, allowing the tissue to become edematous because proteins from the bloodstream leak into the extravascular space, which increases its osmolar load and draws water into the area.Increased porousness of blood vessels also facilitates the entry of inflammatory cells like leukocytes into the wound site from the bloodstream.

 

[drkooks]

yes histamine causes vasodilatation and vascular permeability.
but bradykinin does that too and it causes sustained vasodilatation and permeabilty (i am quoting here from wikipedia)
and hegman factor activates the kinin system ...so i am confused which to choose..
can someone explain and refer to a textbook so we can be sure of right answer???

 

[docdk]

hey u said it urself ...sustained vasodilatation by Hegman factor
ans 3 [confirmed]

 

[briansle]

yes histamine causes vasodilatation and vascular permeability.
but bradykinin does that too and it causes sustained vasodilatation and permeabilty (i am quoting here from wikipedia)
and hegman factor activates the kinin system ...so i am confused which to choose..
can someone explain and refer to a textbook so we can be sure of right answer???

I boiled it down to either Hageman Fact XII or the granuloma.

Hageman's factor stimulates the kinin system which is responsible for killikrein which cleaves kininogen into bradykinin. Bradykinin is similar to histamine.

BRS Pathology does not mention anything about Bradykinin sustaining vasodil and perm properties.

But then again If Wikipedia says otherwise... (I actually had to edit the Wikipedia page on Bradykinin because some clown wrote, "Bradykinin derived from the Brady Bunch."

My intial choice was granuloma because of the words "lasts for days" Chronic Inflammation folks. Only a long period of vasodil and perm would allow the massive accumulation of macrophages and lymphocytes. What is the most cited example of chronic inflammation? The Type 4 hypersensitivity seen in tuberculosis causing caseous necrosis.

Maybe I'm over thinking this...

 

[solan]

the vasodilation and permeability from bradykinin and histamine will not last for days.... will it? should that not make the answer granulation tissue...