mitosis in bone cells

[km1865]

Can someone clarify if my facts are right, I was a unsure as to which bone cells undergo mitosis and which do not.

I think osteogenic cells must undergo mitosis in order to differentiate into osteoblasts. I know osteoblasts are unable to undergo mitosis (but yet they differentiate into osteocytes... can someone explain how differentiation is possible without mitosis?). Similarly, osteocytes cant undergo mitosis. So can osteoclasts undergo mitosis or not? And they are derived separately from osteogenic cells and NOT from osteocytes or osteoblasts, right? Would it be wrong to thikn of osteoprogenitor/osteogenic cells then, as stem cells?

Thanks in advance!

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[km1865]

** actually i read somewhere that osteoclasts are developed from monocytes, in which case they would have to undergo mitosis? also, both volkmann's and haversian canals are teh same thing (besides that they are perpendicular to each other), like both contain lymph AND blood vessels right, or do the volkmanns canals ONLY contain blood vessels and not lymph vessels?

 

[MT Headed]

Can someone clarify if my facts are right, I was a unsure as to which bone cells undergo mitosis and which do not.

I think osteogenic cells must undergo mitosis in order to differentiate into osteoblasts. I know osteoblasts are unable to undergo mitosis (but yet they differentiate into osteocytes... can someone explain how differentiation is possible without mitosis?). Similarly, osteocytes cant undergo mitosis. So can osteoclasts undergo mitosis or not? And they are derived separately from osteogenic cells and NOT from osteocytes or osteoblasts, right? Would it be wrong to thikn of osteoprogenitor/osteogenic cells then, as stem cells?

Thanks in advance!

Osteogenic cells, the bone stem cells, undergo mitosis. Some children remain osteogenic cells, some children become osteoblasts.

Osetoblasts can't do mitosis. They do build bone. The kind of paint themselves into a corner. Then they are called osteocytes, and have different behaviors than when they were osteoblasts. No mitosis necessary to change behavior.

Osteoclasts, the bone destroyers, do not undergo mitosis either. Nobody is really sure where the hell they came from. Some books say they come from monocytes. Some books say they are a merging of several blood-based (not bone-based) stem cells. If it is poorly understood, it won't be tested in the MCAT.

 

[km1865]

thanks, that analogy was really helpful!

 

[deleted329605]

wait...now i'm kinda confused. So the osteogenic cells are the ones that undergo mitosis? and then after one differentiates it becomes an osteoblast that doesn't do mitosis anymore? Do people retain a pool of osteogenic cells throughout their entire life?