MME ?s

[schmee90]

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Greetings all, I have tried to research how MME are actually determined with little success. Does anybody have any good referance articles on how MME was orginally started/determined? Was talking to a colleague who mentioned it was intially started by giving patients differnt meds and asking feedback on how strong these meds were. Sounds pretty out there and I have never been able to find anything online/my ref books other then a bunch of articles on how to calculate MME. I am more interested on how MME was intially deteremined and now changed (ie Tramadol). Thank you in advance.

 

[kstarm]

With limited evidence and a lot of hand waving is my guess. There is this book: Demystifying Opioid Conversion Calculations: A Guide for Effective Dosing which may have some references to how they were determined. I haven't looked at it for quite awhile though.

 

[Ferrismonk]

When I was a fellow, I had 3 different opioid conversion tables in my pocket. My impression was it was based on clinical experience. CDC standardized them in 2016 with their infamous guidelines.

 

[schmee90]

I think I found an answer to my own Q. interestin paper...posted for others to check out if intersted.

The true story of morphine milligram equivalents

They are the foundation of the CDC's 2016 opioid guidelines, resulting in legislation limiting opioid prescribing in 36 states. Morphine milligram equivalents, or MMEs, are used to set arbitrary prescribing limits for opioids by physicians since many state legislators fail to understand — and...

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