Mnemonic: Common Features in Cushing Syndrome

[digitaldoc2002]

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CUSH - gives us signs seen

C -Central Obesity (with peripheral wasting )
U - Unusual brUising
S - Straiae on Skin
H - Hypertension + Hyperglycemia

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[twesting2173]

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[stochastic]

i know that cortisol decreases the tissues sensitivity to insulin which means we'd be hypergylcemic..with break down of amino acids in the periphery as a energy source. but why do we get fat in teh center?

thanks eveyone!

I am not so sure about the cortisol decreasing insulin sensitivity, but that may be...

My understanding is this:

Cortisol is gluconeogenic, leading to hyperglycemia by breaking down muscle amino acids, hence thinner extremities. The hyperglycemia is what leads to hyperinsulinemia. Insulin preferentially distributes the new fat centrally. This is just my take though...