Word. Let me break down my situation. I applied last year, and am on a deferral year. I had a 3.3 from a top 15 undergrad, 30R (10-10-10), good research, leadership, and seventh authorship on a publication (big deal). I got into 6 MDPHDs, 5 of which were MSTPs, had 7 interviews and most of them were in the top 30. Not a great amount of success, but considering my numbers I think I did ok. The key is presentation. Come up with good answers for the basic questions, prepare your apps especially the secondaries to seem like you are a good fit for the school (an often missed part of the application process), make a theme for your application (can change to fit what you percieve to be the focus of the school), and good recs. You should also be able to speak intelligently about your research- what you did, what the general field is doing, how your project fits in, what the future of the field might look like etc. Oh, and I got into 0 MD programs (I applied to more of these than MDPhD) and got 0 MD only interviews (this might have been because I had only a few meaningful clinical experiences). Good Luck.