neurofibromatosis? not sure...

[menniscus]

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Regarding this old question that I found somewhere else...

A 35 yo woman, has had twelce 0.5-1-5 cm cafe au lait marks in her trunk, face, limbs for the past 5 years. what is the most likely diagnosis?
chronic hepatic disease
cushing's sd
HIV infect
melatonin excess
NF1


I was wondering if anyone could explain it to me..people said that it was due to NF1 but regarding the diagnosis criteria I don't really agree.. When do the cafe au lait spots appear? usually early on life right??if they are due to a fail in neural crest migration... melanocites... they shouldn't appear at middle aged... as well as the size should be >15mm ..please help!! 🙂
thanks in advance

 

[Transposony]

It doesn't fit the NF1 diagnostic criteria.
The correct answer is Melatonin excess.

 

[FalconSlice]

Regarding this old question that I found somewhere else...

A 35 yo woman, has had twelce 0.5-1-5 cm cafe au lait marks in her trunk, face, limbs for the past 5 years. what is the most likely diagnosis?
chronic hepatic disease
cushing's sd
HIV infect
melatonin excess
NF1


I was wondering if anyone could explain it to me..people said that it was due to NF1 but regarding the diagnosis criteria I don't really agree.. When do the cafe au lait spots appear? usually early on life right??if they are due to a fail in neural crest migration... melanocites... they shouldn't appear at middle aged... as well as the size should be >15mm ..please help!! 🙂
thanks in advance

It doesn't fit the NF1 diagnostic criteria.
The correct answer is Melatonin excess.

Melatonin? As in the compound that has nothing to do with pigmentation but everything w/circadian rhythms?

 

[Transposony]

Melatonin? As in the compound that has nothing to do with pigmentation but everything w/circadian rhythms?

Sorry about the typo.
I meant Melanin excess.

 

[Jabbed]

Regarding this old question that I found somewhere else...

A 35 yo woman, has had twelce 0.5-1-5 cm cafe au lait marks in her trunk, face, limbs for the past 5 years. what is the most likely diagnosis?
chronic hepatic disease
cushing's sd
HIV infect
melatonin excess
NF1


I was wondering if anyone could explain it to me..people said that it was due to NF1 but regarding the diagnosis criteria I don't really agree.. When do the cafe au lait spots appear? usually early on life right??if they are due to a fail in neural crest migration... melanocites... they shouldn't appear at middle aged... as well as the size should be >15mm ..please help!! 🙂
thanks in advance

Classic buzzword switcharoo.

 

[Transposony]

Classic buzzword switcharoo.

It's a great example of the real test like questions where they will try to use your memorization against you.
That's why it's important to answer the question they are asking rather than the question you want to answer.

 

[syoung]

6 or more cafe au laits, Lisch nodules, bony lesions, optic glioma, 2 or more neurofibromas (benign growths of schwannomas), 1st deg relative w/ NF1, intertriginous freckles <strike>How many needed for criteria? At least 2 beyond the cafe au lait?</strike>

nevermind i answered my own question. it is 2 or more of the listed criteria

 

[menniscus]

Thanks for the repplies but I still didn't get what is the answer...

 

[theTruth_97]

anyone know what the answer is?

 

[Transposony]

anyone know what the answer is?

Anyone is welcome to prove me wrong but I believe it's not a valid question (likely a typo between Melatonin and Melanin).
Does anyone knows the source of this question?

 

[dfib slim]

anyone know what the answer is?

Maybe it's chronic hepatic disease leading to increased estrogen levels and resulting increased melanin production?

 

[menniscus]

it was from a really old exam, NBME 1, i found the exam somewhere and it was a pic of the question, so i guess it should have been difficult to change it rigth?
maybe it was an errata or maybe it s sth related to the chronic hepatic disease, as dfib slim said..
It could be some kind of cloasma-melasma like ? (I know that cloasma appears in the face)
due to decrease clearence of strogens? maybe this is the physiopathology of it, I just made it up.. . I mean I ve never heard about it, but could it be a quite reasonable answer..?

 

[Transposony]

This is the original question (except the picture which is very similar):

A 35-year-old woman has had twelve 0.5 to 1.5-cm lesions on her neck, trunk, and limbs for the past 5 years. A lesion on her arm is shown. Which of the following is the most likely diagnosis?
A Chronic hepatic disease
B Cushing's syndrome
C HIV infection
D Melatonin excess
E Neurofibromatosis

Could they be asking about Neurofibromatosis type 6 ? aka neurofibromatosis type 1-like syndrome

 

[Mr. Mojo Risin]

This is the original question (except the picture which is very similar):



Could they be asking about Neurofibromatosis type 6 ? aka neurofibromatosis type 1-like syndrome

Not sure. They don't specify subtype of NF in the answer choice, but they're probably just testing our ability to identify a CAL spot.

 

[NormanJ]

Hey sorry for the late answer. But I believe its NF1. I know this because I was born with NF1