Ochem question

[rdhdds1]

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I am having a tough time keeping Sn1/Sn2/E1/E2 straight. Any suggestions?

Also, when looking at a reagent how can you tell which way it will go (e.g Sn1/Sn2/E1/E2)?

How can I remember when to invert?

My test is in 2 days and I am either losing brain cells or have so much information in my head that I am confusing myself! Help!

 

[Albuterol]

http://www.wfu.edu/~wrightmw/chm122/handouts/sn1sn2e1e2%20summary.pdf
http://faculty.northseattle.edu/jpatterson/chem238/pdf/235sn1sn2.pdf

invert when u undergo an SN2 rxn.

 

[klutzy1987]

I am having a tough time keeping Sn1/Sn2/E1/E2 straight. Any suggestions?

Also, when looking at a reagent how can you tell which way it will go (e.g Sn1/Sn2/E1/E2)?

How can I remember when to invert?

My test is in 2 days and I am either losing brain cells or have so much information in my head that I am confusing myself! Help!

Ok here it is.
SN2 favors a strong Nucleophile and a good leaving group and needs a polar aprotic solvent. It also only works by a primary or secondary due to steric hinderance of a tertiary towards the attcking nucleophile. There is a 100% inversion of steriochemistry.

SN1 is leaving group specific, and favors Polar protic solvents. It will only work On tertiary and secondary because it uses a carbocation intermediate. There is a partial inversion of steriochemistry.

E2- Will happen when one of the 5 Dr j.'s cutting tools is used. (methoxide, ethoxide,terbutoxide, i cant remember the other 2 offhand). The halogen though needs to be tertiary, not the primary. The primary will undergo SN2. The Elimination is Zaitchev with the exception of terbutoxide which due to its size and big bulky steric hinderance which will go Hoffman.

E1- All other eliminations will go E1, like KOH, NaOH and other bases that arent one of the 5 cutting tools.

Any questions just ask and i will do my best to answer them.

 

[PChemGrad]

Just remember in your O-Chem class on a molecule when it shows R.
R is anything: methyl, ethyl, your mom...