OD's: Quick drug interaction question

[chacem]

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Hey, I just have a question for y'all.

Does tobradex interact with oral contraceptives?

Tobradex= eye antibiotic
contraceptive= novcon 50.


Thanks! (I'm ****ting bricks right now, btw)

 

[canadiancal]

Nope. The only proven antibiotic that interacts is rifampin

Hey, I just have a question for y'all.

Does tobradex interact with oral contraceptives?

Tobradex= eye antibiotic
contraceptic= novcon 50.


Thanks! (I'm ****ting bricks right now, btw)

 

[chacem]

Thanks for the fast response, man. I appreciate it more than you would ever know!

What family of AB is tobradex?

 

[canadiancal]

aminoglycoside

Thanks for the fast response, man. I appreciate it more than you would ever know!

What family of AB is tobradex?

 

[chacem]

Thanks!

Don't Antibiotics like Penicillin also decrease the effectiveness of BC, though?

 

[canadiancal]

In theory yes. In could disrupt the enterohepatic recirculation of the glucoronide conjugate...but has never been proven to be the case. I always tell my patients the risk is 1000x more likely to happen if you take your OC incorrectly.

Thanks!

Don't Antibiotics like Penicillin also decrease the effectiveness of BC, though?

 

[chacem]

great. Just what I needed to hear. Thanks man.

 

[ituryu]

Nope. The only proven antibiotic that interacts is rifampin

What sort of interaction are you talking about, pls be specific. Thanks

 

[canadiancal]

Decreased effectiveness of Oral contracteptives.

What sort of interaction are you talking about, pls be specific. Thanks

 

[rpie]

Thanks for the fast response, man. I appreciate it more than you would ever know!

What family of AB is tobradex?

FYI, it’s actually a combo antibiotic/steroid. Tobramycin & Dexamethasone. I agree with Cana, don't worry too much.

 

[canadiancal]

Just for clarification or for interest, the theory is as follows:
the antibiotic destroys the normal flora (bacteria) in the intestine that is responsible for the linkage with glucoronide (acts like a carrier) and reuptake of the hormones from the intestine. Therefore, a decrease in hormone levels could occur....but has never been clinically proven except for Rifampin.
Dexamethasone..has no effect whatsoever on OC.
I

FYI, it’s actually a combo antibiotic/steroid. Tobramycin & Dexamethasone. I agree with Cana, don't worry too much.

 

[Richard_Hom]

Just for clarification or for interest, the theory is as follows:
the antibiotic destroys the normal flora (bacteria) in the intestine that is responsible for the linkage with glucoronide (acts like a carrier) and reuptake of the hormones from the intestine. Therefore, a decrease in hormone levels could occur....but has never been clinically proven except for Rifampin.
Dexamethasone..has no effect whatsoever on OC.
I

Dear Forum,

What do you suppose is the systemic absorption of topical tobradex?

Richard

 

[Andrew_Doan]

Dear Forum,

What do you suppose is the systemic absorption of topical tobradex?

Richard

Can be good depending on its chemical properties.

http://www.ncbi.nlm.nih.gov/entrez/...ed&dopt=Abstract&list_uids=1472144&query_hl=3

http://www.ncbi.nlm.nih.gov/entrez/...ed&dopt=Abstract&list_uids=6131541&query_hl=3

http://www.ncbi.nlm.nih.gov/entrez/...med&dopt=Abstract&list_uids=508681&query_hl=3 (based on this paper, likely low if given topically)

http://www.ncbi.nlm.nih.gov/entrez/...med&dopt=Abstract&list_uids=508680&query_hl=3