Hmm, well if a compound is chiral, it is optically active. Recall that a chiral molecule has 4 different substituents attached to the chiral center. Each group would therefore have a unique dipole, and the addition of all unique vectors would result in a net dipole moment. Groups can be electron withdrawing or electron donating.
For meso compounds, there can be conflicting chiral centers, that cancel the optical rotations of each other. This can be seen in molecules that have a plane of symmetry and net dipoles of the substituents exactly cancel each other out. This sort of molecule would be non polar and optically inactive.
