Oxecta (aka Acurox...)

[WVUPharm2007]

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...finally got its approval.

I give the Bubbles' out there a good week before they figure out a way around this new "AVERSION technology".

Some of those bastards have a better understanding of the solubility, boiling points, and extractability of oxycodone than a Med Chem PhD.

 

[npage148]

Some liq-liq extractions and BAM, Pure oxy. AND I'm not sure what some niacin flushing is gonna do to discourage people from taking a handful

 

[rph3664]

When I was in high school ca. 1980, long before I decided to become a pharmacist, some people proposed putting ipecac in tranquilizers and narcotics so people who OD'd would throw them up and not die.

Sounds like a good idea, doesn't it? Never made it to market.

 

[aboveliquidice]

...finally got its approval.

I give the Bubbles' out there a good week before they figure out a way around this new "AVERSION technology".

Some of those bastards have a better understanding of the solubility, boiling points, and extractability of oxycodone than a Med Chem PhD.

I was wondering the same thing... I wonder if we can find the cross post on the illegal drug use forum??? You know it's a mission at this point in the game.

 

[ttopping]

When I was in high school ca. 1980, long before I decided to become a pharmacist, some people proposed putting ipecac in tranquilizers and narcotics so people who OD'd would throw them up and not die.

Sounds like a good idea, doesn't it? Never made it to market.

Not so sure about that. I've seen some pretty high doses of narcotics used in patients with chronic pain. Doses that for me, someone who is opiate naive, would probably be an OD. How would they decide the amount of ipecac to be used per dose? Not to mention ipecac isn't recommended for ODing anymore anyway.

 

[Praziquantel86]

That would make for an incredibly fun ipecac challenge.

 

[rph3664]

Not so sure about that. I've seen some pretty high doses of narcotics used in patients with chronic pain. Doses that for me, someone who is opiate naive, would probably be an OD. How would they decide the amount of ipecac to be used per dose? Not to mention ipecac isn't recommended for ODing anymore anyway.

And that is one of a multitude of reasons why it isn't the good idea it appeared to be on the surface! No, ipecac isn't recommended now for poisoning, but it was at the time.

A lady I used to work with said that when she was in retail, some kids who worked at that store said, "Is it really true that this stuff will make you puke?" She replied, "YES!" and they didn't believe her, and purchased it.

😱

I've read about bulimics who used it - ONCE. They didn't want to purge THAT badly.

 

[npage148]

That would make for an incredibly fun ipecac challenge.

The winner gets aspiration pneumo?👍

 

[rph3664]

The first time I saw this, it was in a movie theater with a couple hundred other people who also didn't know this scene was in the movie.

http://www.youtube.com/watch?v=qBCSMjHJAvg

I never heard people howl that loud in a theater until I saw "About Schmidt", also in a theater with a few hundred people who did not know about the full nudity scene featuring Kathy Bates. 👍

 

[deleted205891]

There are no studies testing the abuse potential of Oxecta vs. oxycodone IR.
BTW I cannot find any studies for this product on pubmed (since PubMed doesn't search by brand name), and I thought this would make a good DI writeup for my current rotation (hospital). The PI for it can finally be accessed (it was inaccessible earlier today).

 

[ethyl]

I've already heard patients know of a method around the gelling mechanism and how to get to the oxycodone center. Probably not a good idea for me to go into detail. :/

 

[rph3664]

I've already heard patients know of a method around the gelling mechanism and how to get to the oxycodone center. Probably not a good idea for me to go into detail. :/

Are you gellin'?

http://www.youtube.com/watch?v=a6EiqcuGpV4

 

[confettiflyer]

There are no studies testing the abuse potential of Oxecta vs. oxycodone IR.
BTW I cannot find any studies for this product on pubmed (since PubMed doesn't search by brand name), and I thought this would make a good DI writeup for my current rotation (hospital). The PI for it can finally be accessed (it was inaccessible earlier today).

I don't think they were going for a specific indication for the curbing of abuse potential. Actually, my guess is the FDA couldn't give that indication purely because the thing is tough to break apart.

I'm guessing there are a few epidemiological studies ongoing and an in a few years they'll snag the indication for abuse potential if the studies pan out.

I think Remoxy (oxycodone ER tamper resistant) has a PDUFA date coming up.

Also I think there was an article a while back about addicts moving over to heroin because they couldn't get high with oxy AND heroin was cheaper.

 

[Ackj]

I think Remoxy (oxycodone ER tamper resistant) has a PDUFA date coming up.

I think I read the 23rd, so tomorrow I guess?

 

[rph3664]

If nothing else, they'll be treating their high cholesterol and preventing pellagra at the same time! Malnutrition is a huge problem in addiction, you know.

 

[Ackj]

Also I think there was an article a while back about addicts moving over to heroin because they couldn't get high with oxy AND heroin was cheaper.

http://www.time.com/time/world/article/0,8599,2078355,00.html#ixzz1Puyb832o

Here's an article I saw today about the next step. Can't get any cheap heroin in Russia, so it goes further down the line to something even more dangerous. Not saying this will necessarily happen here, but you'd be a fool to think that abuse-deterrent formulations will outright stop junkies. They'll get their fix someway.


Some explicit pictures of that nasty Russian drug in the following link. Oddly enough, they can buy codeine OTC and cook it up.
http://animalnewyork.com/2011/06/flesh-rotting-cheap-heroin-alternative-is-hot-in-russia/

 

[Praziquantel86]

http://animalnewyork.com/2011/06/flesh-rotting-cheap-heroin-alternative-is-hot-in-russia/

Here's an article I saw today about the next step. Can't get any cheap heroin in Russia, so it goes further down the line to something even more dangerous. Not saying this will necessarily happen here, but you'd be a fool to think that abuse-deterrent formulations will outright stop junkies. They'll get their fix someway.


Some explicit pictures of that nasty Russian drug in the following link. Oddly enough, they can buy codeine OTC and cook it up.
http://animalnewyork.com/2011/06/flesh-rotting-cheap-heroin-alternative-is-hot-in-russia/

That's up there with the most disgusting things I've ever seen. I don't understand how people can willingly do that to themselves in the first place or how the government stands idly by while it happens.

 

[xiphoid2010]

That's up there with the most disgusting things I've ever seen. I don't understand how people can willingly do that to themselves in the first place or how the government stands idly by while it happens.

that's addiction -- continued behavior even when aware of the detrimental effects.

I am more surprised that the ones in the pictures didn't die from septic shock.

 

[Praziquantel86]

that's addiction -- continued behavior even when aware of the detrimental effects.

I am more surprised that the ones in the pictures didn't die from septic shock.

They do - read the article that the website links to (in Time). Life expectancy for users is ~1 year.